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ProteomicsCotL, a new morphogenetic coat protein of Clostridium difficile
The strict anaerobe Clostridium difficile is an important nosocomial enteropathogen that has become the most common cause of antibiotic-associated diarrhea. The oxygen-resistant C. difficile spores play a central role in the infectious cycle, contributing to transmission, infection and recurrence. T...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2019-10-16 | PXD010359 | Pride
Spore coat Shotgun proteomics Q exactive hf Clostridium difficile 
ProteomicsThe cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile
The ability of bacterial pathogens to establish recurrent and persistent infections is frequently associated with their ability to form biofilms. Clostridioides difficile infections have a high rate of recurrence and relapses and it is hypothesised that biofilms are involved in its pathogenicity and...
ORGANISM(S): Escherichia coli 
2023-05-16 | PXD038282 | Pride
Cd1687 Biofilm Clostridioides difficile 
ProteomicsThe role of the Ser/Thr kinase PrkC of Clostridium difficile in cell wall homeostasis and antimicrobial resistance.
Clostridium difficile is the leading cause of antibiotic associated diarrhea in adults. During infection, the bacteria must rapidly respond and adapt to the host environment by being able to activate survival strategies. Ser/Thr kinases (STKs) are involved in signal transduction and regulate numerou...
ORGANISM(S): Clostridioides difficile 
2019-06-14 | PXD012241 | Pride
Qexactive hf Clostridium difficile Cell wall Shotgun proteomics 
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