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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
GenomicsBittarella massiliensis (ex Durand et al. 2017) strain:GGCC_0305
Bittarella massiliensis (ex Durand et al. 2017) strain:GGCC_0305 Genome sequencing and assembly
PRJNA628682 | ENA
TranscriptomicsTelomeric repeats facilitate CENP-A incorporation via telomere binding proteins
The histone H3 variant, CENP-ACnp1, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined. To explore the tolerances and constraints on CENP-ACnp1 depositio...
ORGANISM(S): Schizosaccharomyces pombe 
2013-08-22 | E-GEOD-46427 | biostudies-arrayexpress
TranscriptomicsOdontoblast-like cells and dental pulp fibroblasts stimulated with LTA, poly(I:C) and LPS.
Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the carious process. To determine whether they differ in their responses to oral pathogens, we performed a systematic co...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9560 | biostudies-arrayexpress
ProteomicsInteractions between H. kunzii and S. aureus: How a commensal bacterium modulates the virulence and metabolism of a pathogen in a chronic wound model
This study aims at elucidate the molecular mechanisms underlying the interaction between H. kunzii and S. aureus
ORGANISM(S): Helcococcus kunzii Staphylococcus aureus 
2024-11-06 | PXD049416 | Pride
Proteomics Bacterial interaction Mass spectrometry 
TranscriptomicsIdentification of a methylome signature of esophageal squamous cell carcinoma
Background & Aims: Esophageal squamous cell carcinoma (ESCC) is believed to arise from esophageal mucosa through accumulation of both genetic and epigenetic changes. DNA methylation is a critical epigenetic mechanism involved in key cellular processes and its deregulation has been linked to many hum...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-26784 | biostudies-arrayexpress
TranscriptomicsDeletion of Clr3 restores expression of a subset of genes in gcn5- mutant cells
Histone acetylation and deacetylation is important for gene regulation. The histone acetyltransferase, Gcn5, is a known activator of transcriptional initiation that is recruited to gene promoters. Here we map genome-wide levels of Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predom...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-24 | E-GEOD-13817 | biostudies-arrayexpress
Transcriptomicsdrought and salt stress response-Eskimo gene characterisation.
ra06-02_staygreen - drought and salt stress response - Modification of the transcriptome by the eskimo mutation and response to stress. - Individual plants were grown in Fertiss clods in a culture chamber. 3 treatments were made to the plants : control, drought and salt. Keywords: gene knock out,tre...
ORGANISM(S): Arabidopsis thaliana 
2008-09-10 | E-GEOD-10384 | biostudies-arrayexpress
UnknownPreclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients.
Not available
S-EPMC6334931 | biostudies-literature
TranscriptomicsCharacterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.
Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alter...
ORGANISM(S): Homo sapiens 
2011-04-09 | E-GEOD-28476 | biostudies-arrayexpress
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