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TranscriptomicsProspective derivation of a 'Living Organoid Biobank' of colorectal cancer patients
In Rspondin-based three-dimensional cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their tissue identity. Here we report the establishment of tumor organoid cultures from 20 consecutive colorectal carcinoma (CRC) patients. For most, organoids were...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-65253 | biostudies-arrayexpress
UnknownSpatial spillover impact of determinants on child mortality in Pakistan: evidence from Spatial Durbin Model.
Not available
S-EPMC10464234 | biostudies-literature
TranscriptomicsRNA-seq of WT, Mbd3-/- and rescue hiPSC during neuroectodermal differentiation and of WT and Mbd3-/- in mEpiSC during neuroectodermal differentiation
Differentiation of mammalian pluripotent cells involves large-scale changes in transcription and chromatin remodellers are essential to initiate, establish and maintain a new gene regulatory network. In this study, we investigated the structure and function of the nucleosome remodeller and deacetyl...
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-8753 | biostudies-arrayexpress
UnknownHuman parainfluenza virus type 3 (PIV3) expressing the hemagglutinin protein of measles virus provides a potential method for immunization against measles virus and PIV3 in early infancy.
Not available
S-EPMC112199 | biostudies-literature
TranscriptomicsYeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts [RNA-seq]
Functional characterization of the Xap5 protein using epistatic genetic interaction analysis (E-MAP), RNA-seq and ChIP-chip along with other growth experiments. wild type and mutant cells were grown at 37C in EMM50 and RNA was extracted from exponentially growing cells. Strand specific libraries wer...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-01 | E-GEOD-46382 | biostudies-arrayexpress
TranscriptomicsCrohn's disease risk variant in GPR65 alters lysosomal function
Using an siRNA screen we identify a role for GPR65 in the defense against intracellular pathogens. Epithelial cells and macrophages lacking GPR65 exhibited impaired clearance of intracellular bacteria as well as an accumulation of aberrant phagosomes and lysosomes. Transcriptional profiling revealed...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-69445 | biostudies-arrayexpress
UnknownAn examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood.
Not available
S-EPMC2583465 | biostudies-literature
UnknownSpatialtemporal evolution characteristics of ozone in China and its response to urbanization.
Not available
S-EPMC11142485 | biostudies-literature
UnknownStudy on the relationship between buyer market power, spatial spillover effect, and profit in China's pharmaceutical industry.
Not available
S-EPMC12660219 | biostudies-literature
UnknownSpatial and Temporal Analyses of the Event of Death for 1480 in Milan Using the Data Contained in the Sforza's Registers of the Dead.
Not available
S-EPMC9956338 | biostudies-literature
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