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TranscriptomicsDUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small cell lung cancer
DUSP1 is involved in different cellular pathways including cancer cell proliferation, angiogenesis, invasion and resistance to chemotherapy. To understand more about the cellular responses regulated by DUSP1 in NSCLC cells, we interfered DUSP1 expression in the NSCLC cell line H460 and studied the c...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-19592 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spleens from dual specificity phosphatase-1 (DUSP1) deficient and wild type mice to demonstrate a specific regulatory role of DUSP1 on a subset of LPS-induced genes that control the outcome of endotoxin shock.
Activation of the Mitogen activated protein kinase (MAPK) cascade following Toll-like receptor (TLR) stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we iden...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3565 | biostudies-arrayexpress
Transcriptomicsp38alfa and ATF2 act differentially depending on DUSP1 expression in NCSCL in response to cisplatin
DUSP1 is involved in different cellular pathways including cancer cell proliferation, angiogenesis, invasion and resistance to chemotherapy. To gain insight into the cellular signaling pathways involving DUSP1 actions and the response to Cisplatin (CDDP) in non small cell lung cancer (NSCLC), we hav...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-26704 | biostudies-arrayexpress
GenomicsDUSP1 deletion is synthetic lethal to JAK2V617F induced MPN
DUSP1 deletion is synthetic lethal to JAK2V617F induced MPN
PRJNA954008 | ENA
TranscriptomicsTherapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma through derepression of DUSP1 phosphatase and inhibition of ERK
We have investigated the role of the Notch pathway in the generation and maintenance of KrasG12V-driven non-small cell lung carcinomas (NSCLCs). We demonstrate by genetic means that γ-secretase and Rbpj activities are both essential in the formation of NSCLCs. Interestingly, pharmacologic treatment ...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-38054 | biostudies-arrayexpress
GenomicsmPFC DUSP1 mediates adolescent cocaine exposure-induced higher sensitivity to drug in adulthood
mPFC DUSP1 mediates adolescent cocaine exposure-induced higher sensitivity to drug in adulthood
PRJNA962986 | ENA
TranscriptomicsControl of LPS-response by DUSP1
Activation of the Mitogen activated protein kinase (MAPK) cascade following Toll-like receptor (TLR) stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we iden...
ORGANISM(S): Mus musculus 
2005-12-15 | GSE3565 | GEO
GenomicsDUSP1 and SOX2 expression determine Squamous cell carcinoma of the salivary gland progression.
DUSP1 and SOX2 expression determine Squamous cell carcinoma of the salivary gland progression.
PRJNA1065852 | ENA
GenomicsLoss of DUSP1 expression creates a cold tumor microenvironment in cutaneous squamous cell carcinoma
Loss of DUSP1 expression creates a cold tumor microenvironment in cutaneous squamous cell carcinoma
PRJNA1084005 | ENA
GenomicsDual specificity phosphate 1 (DUSP1) has a key non-invasive predictive marker in preeclampsia
Dual specificity phosphate 1 (DUSP1) has a key non-invasive predictive marker in preeclampsia
PRJNA1090471 | ENA
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