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TranscriptomicsWTS of breast cancer samples
Whole transcriptome sequencing was performed on tumors collected from patients before and after hydroxyprogesterone exposure and controls. By comparing the gene expression patterns in exposed and unexposed groups, we aim to understand the molecular basis of action of hydroxyprogesterone on primary b...
ORGANISM(S): Homo sapiens 
2024-02-10 | E-MTAB-11412 | biostudies-arrayexpress
TranscriptomicsDifferential regulation of SGK1 by progesterone activates AP-1/NDRG1 genomic axis in PR-positive and negative breast cancer cells
Pre-operative progesterone intervention has been shown to confer a survival benefit to breast cancer patients independent of their progesterone receptor (PR) status, raising a question about how progesterone affects the outcome of PR-negative cells. Here, we identify up-regulation of a Serum- and gl...
ORGANISM(S): Homo sapiens 
2018-10-19 | E-MTAB-6742 | biostudies-arrayexpress
GenomicsTMC-SNPdb: An Indian germline variant dataset derived from whole exome sequence
Cancer is predominantly a somatic disease. A mutant allele found in cancer cell genome is considered somatic when it is absent in paired normal genome and dbSNP, the most comprehensive public SNP database. However, dbSNP inadequately represents several non-Caucasian populations including that from t...
ORGANISM(S): Homo sapiens 
2018-06-06 | E-MTAB-4618 | biostudies-arrayexpress
GenomicsWhole exome sequencing of human tumours and cell lines to investigate how ERBB2 and KRAS Alterations mediate response to EGFR inhibitors in early stage Gallbladder Cancer
Purpose: The uncommonness of gallbladder cancer in the developed world has contributed to the generally poor understanding of the disease. The development of new and effective treatment has been and continues to be a major public health imperative. Methods: We report mutational and copy number ana...
ORGANISM(S): Homo sapiens 
2018-12-29 | E-MTAB-6619 | biostudies-arrayexpress
TranscriptomicsWhole Transcriptome sequencing TSCC (tongue squamous cell carcinoma)
Of the multiple anatomical sites represented in oral cancer, squamous cell carcinoma of the tongue (TSCC) shows the highest incidence among younger age group. Chewing betel leaf, areca nut & slaked lime and smoking tobacco are common practises in India which have direct clinical implication in TSCC ...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-4654 | biostudies-arrayexpress
GenomicsWhole exome sequencing of EGFR-TKI naive and EGFR-TKI resistant lung adenocarcinoma samples
Whole exome sequencing was performed on set of 48 DNA samples obtained from 16 EGFR mutated NSCLC patients whose tumors progressed following EGFR-TKI treatment. The DNA samples included baseline biopsy, rebiopsy and blood from the same patient. By comparing the variants in rebiopsy tumors and baseli...
ORGANISM(S): Homo sapiens 
2022-02-11 | E-MTAB-11404 | biostudies-arrayexpress
GenomicsWhole exome sequencing of TSCC (tongue squamous cell carcinoma)
Of the multiple anatomical sites represented in oral cancer, squamous cell carcinoma of the tongue (TSCC) shows the highest incidence among younger age group. Chewing betel leaf, areca nut & slaked lime and smoking tobacco are common practises in India which have direct clinical implication in TSCC ...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-4653 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of human breast cancer cell lines treated and untreated with progesterone
To investigate the progesterone responsive long non-coding RNAs in human breast cancer cells. Cells were treated with 10nM of progesterone for 6 hours and cells were collected in Trizol for total RNA extraction. Total RNA sequencing was performed. Differential expression analysis was performed to id...
ORGANISM(S): Homo sapiens 
2024-07-08 | E-MTAB-11925 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of Cervical Adenocarcinoma
The whole-genome sequencing raw data comprises of 3 paired samples of cervical adenocarcinoma subtype.
ORGANISM(S): Homo sapiens 
2025-11-09 | E-MTAB-9289 | biostudies-arrayexpress
TranscriptomicsWhole Transcriptome Sequencing of Cervical Adenocarcinoma
The raw data consists of Transcriptome sequencing of 24 tumor samples and 5 normal samples of cervical adenocarcinoma samples
ORGANISM(S): Homo sapiens 
2022-02-11 | E-MTAB-9281 | biostudies-arrayexpress
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