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TranscriptomicsMKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells.
Though mitogen activated protein kinase kinases (MKK or MEK) 1 and 2 are widely assumed to be functionally redundant some reports indicate they possess distinct biologic activities. To test the hypothesis that MEK1 and MEK2 signaling pathways are interchangeable we used two complementary approaches...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-23930 | biostudies-arrayexpress
TranscriptomicsRenal Cell Carcinoma - Papillary types 1, and 2b, Normal Kidney Tissue
Myc oncogenic signature in Papillary type 2b Keywords: Gene Expression experiment Tumor samples compared to Normal renal tissue
ORGANISM(S): Homo sapiens 
2007-06-12 | E-GEOD-7023 | biostudies-arrayexpress
TranscriptomicsChromophobe and Oncocytoma Renal Cell Carcinomas: gene expression and SNP analysis
Chromosomal abnormalities, such as structural and numerical abnormalities, are a common occurrence in cancer. The close association of homologous chromosomes during interphase, a phenomenon termed somatic chromosome pairing, has been observed in cancerous cells, but the functional consequences of so...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-8271 | biostudies-arrayexpress
TranscriptomicsPBRM1 Knockdown in RCC Cell Lines
PBRM1 was found to be mutated in a high percentage of clear cell RCCs. We performed knockdown of PBRM1 via siRNA and compared with scrambled control in three different RCC cell lines. PBRM1 siRNA and mock treated cell lines were normalized together with 'hypoxic' clear cell renal tumors and normal r...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-22316 | biostudies-arrayexpress
TranscriptomicsSomatic Mutation Screen of Clear Cell RCC I
Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic mutations in each sample can be found at http://www.sanger.ac.uk/genetics/CGP/Studies/. These samples were run at a different facility than VARI - scmmlab.com Correlat...
ORGANISM(S): Homo sapiens 
2010-01-04 | E-GEOD-17816 | biostudies-arrayexpress
TranscriptomicsSomatic Mutation Screen of Clear Cell RCC II
Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic mutations in each sample can be found at http://www.sanger.ac.uk/genetics/CGP/Studies/. Correlating gene expression profiling with mutational status
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17818 | biostudies-arrayexpress
TranscriptomicsOncogenic potential of RAS isoforms in melanocytes
We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weak...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-6194 | biostudies-arrayexpress
TranscriptomicsAngiosarcoma gene expression
A comparison of gene expression in OCT frozen human angiosarcoma compared with OCT frozen normal mesenchymal tissues RNA was isolated from 18 AS and normal human. RNA was isolated from 3 kidney and 2 skeletal muscle OCT frozen sections and 3 samples of frozen whole blood. Twenty-five nanograms of to...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-44115 | biostudies-arrayexpress
TranscriptomicsExpression profiling of ccRCC samples treated with anti-VEGF therapies reveals distinct markers
Metastatic renal cell carcinoma (mRCC) patients treated with anti-vascular endothelial growth factor (VEGF) therapies demonstrate promising outcomes but not all patients benefit. Factors that predict response remain to be elucidated. Nephrectomy material from 37 patients with mRCC receiving bevacizu...
ORGANISM(S): Homo sapiens 
2011-01-07 | E-GEOD-25698 | biostudies-arrayexpress
TranscriptomicsSomatic Mutation Screen of Clear Cell RCC
This SuperSeries is composed of the following subset Series: GSE17816: Somatic Mutation Screen of Clear Cell RCC I GSE17818: Somatic Mutation Screen of Clear Cell RCC II Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17895 | biostudies-arrayexpress
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