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TranscriptomicsTranscription profiling of human T98G during asynchronous growth or under growth arrest by serum deprivation or contact inhibition
Triplicate experiments from T98G cells under asynchronously growing, and growth arrest by serum deprivation and contact inhibition.
ORGANISM(S): Homo sapiens 
2007-11-06 | E-GEOD-1692 | biostudies-arrayexpress
TranscriptomicsPaf1C plays novel subunit-specific roles in alternative cleavage and polyadenylation
The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and PolII elongation. Here, we provide the first genome-wide analysis of chromatin occupancy by the entire PAF complex in mammalian cells. We show that Paf1C is recruited not only to promoters and gene bo...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-72574 | biostudies-arrayexpress
GenomicsA role for H3K4 mono-methylation in facultative heterochromatin assembly and partitioning of chromatin readers
Mono-methylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of enhancers and promoters, although its function is unknown. Remarkably, we find H3K4me1 at the promoter regions of conditionaly-repressed muscle and stimulus-dependent inflammatory response genes in myoblasts. Durin...
ORGANISM(S): Mus musculus 
2014-03-29 | E-GEOD-50590 | biostudies-arrayexpress
GenomicsDynamic loss of H2B ubiquitylation without corresponding changes in H3K4 tri-methylation during myogenic differentiation
Ubiquitylation of H2B on lysine 120 (H2Bub) is associated with active transcriptional elongation. H2Bub has been implicated in histone cross-talk and is generally regarded to be a prerequisite for H3K4 and H3K79 tri-methylation in both yeast and mammalian cells. We performed a genome-wide analysis o...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-34960 | biostudies-arrayexpress
GenomicsGenome-wide remodeling of the epigenetic landscape during myogenic differentiation
We have examined changes in the chromatin landscape during muscle differentiation by mapping the genome-wide location of ten key histone marks and transcription factors in mouse myoblasts and terminally differentiated myotubes, providing an exceptionally rich dataset that has enabled discovery of ke...
ORGANISM(S): Mus musculus 
2011-05-08 | E-GEOD-25308 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptional regulation of starvation-induced atrophy and autophagy programs by Foxk1 and Sin3A
Autophagy is the primary catabolic process triggered in response to starvation. Although autophagic regulation within the cytosolic compartment is well established, it is becoming clear that nuclear events also regulate the induction or repression of autophagy. Nevertheless, a thorough understanding...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-56932 | biostudies-arrayexpress
GenomicsGenome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes
Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and phy...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22554 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary skin fibroblasts throughout the cell cycle after synchronization by serum starvation or by serum starvation and thymidine blocking
Not available
ORGANISM(S): Homo sapiens 
2008-01-03 | E-TABM-263 | biostudies-arrayexpress
GenomicsGenome-wide identification of enhancers in skeletal muscle
In an effort to identify the compendium of regulatory elements that govern myogenic differentiation, we generated chromatin state maps based on the recruitment of factors (p300 and PolII) and histone modifications (H3K4me1, H3K27ac) that typify enhancers in myoblasts and myotubes. We found a remarka...
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-37525 | biostudies-arrayexpress
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