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Because myostatin normally limits skeletal muscle growth, there is an extensive effort to develop myostatin inhibitors for clinical use. One potential concern is that in patients with muscle degenerative diseases, inducing hypertrophy may increase stress on dystrophic fibers. Here, we show that bl...
ORGANISM(S): Mus musculus 
Spinal Muscle Degeneration in Dysferlinopathy Affects Gait and Identifies Cellular and Therapeutic Target
Unlike axial myopathy, which is primarily associated with weakness in the spinal muscles, Limb Girdle Muscular Dystrophy 2B/R2 (LGMD2B/R2; dysferlinopathy) causes loss of limb as well as pelvic and shoulder girdle muscles. However, spinal pathology is often reported in dysferlinopathy patients. Thro...
ORGANISM(S): Mus musculus 
2026-08-31 | GSE333908 | GEO
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