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MetabolomicsExcoriation Disorder Is Characterized by Systemic Glutamatergic Dysfunction

Excoriation disorder (ED), also known as neurotic excoriations, is a psychocutaneous disorder characterized by repetitive, compulsive picking of the skin leading to secondary tissue damage. ED carries an estimated prevalence of 1.4%, and is associated with significant social dysfunction, as patie...

2024-04-03 | MTBLS9118 | MetaboLights
MetabolomicsACOD1 deficiency promotes dermal papilla cell senescence via mitochondrial dysfunction in androgenetic alopecia

Background Androgenetic alopecia (AGA), the most prevalent form of hair loss, is driven by the dysfunction of dermal papilla cells (DPCs). Emerging evidence implicates DPC senescence in the pathogenesis of AGA; however, the underlying molecular mechanisms remain incompletely elucidated.

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2026-05-23 | MTBLS14024 | MetaboLights
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
MetabolomicsComprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart
The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet a...
2015-11-17 | MTBLS173 | MetaboLights
MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
MetabolomicsGenetic Ablation of Sfxn5 Induces Mitochondrial Dysfunction and Precipitates Lethal Metabolic Crisis in Mice
Mitochondrial disorders frequently manifest with life-threatening hepatic metabolic crises. Using a global Sfxn5-knockout mouse model, we investigated the systemic consequences of disrupting this mitochondrial inner-membrane transporter through integrated biochemical, metabolomic, histological, and ...
2026-05-30 | MTBLS14628 | MetaboLights
MetabolomicsNGT induced mitochondrial dysfunction, led to apoptosis, and changed metabolites associated with oxidized lipids in sperm of Pacific oyster (Crassostrea gigas).

The risk of norgestrel (NGT) exposure in the aquatic environment has been identified, but the toxic effects on invertebrate germ cells are unknown. Therefore, the toxic effects of NGT on oyster sperm were investigated by combining transcriptome and metabolome analysis with histology. Transcriptom...

2025-07-05 | MTBLS12685 | MetaboLights
MetabolomicsMitochondrial Transplantation Ameliorates Doxorubicin-Induced Cardiac Dysfunction via Activating Glutamine Metabolism
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
2025-03-13 | MTBLS7989 | MetaboLights
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