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MetabolomicsGut Microbiota and Metabolomic Changes Across Preterm Stages: Potential Associations with Bronchopulmonary Dysplasia

The coordinated postnatal development of the gut microbiome and metabolome is essential for preterm infant health, yet its disruption is increasingly linked to adverse outcomes such as bronchopulmonary dysplasia (BPD). In this study, we performed an integrated multi-omics analysis of fecal sample...

2026-02-05 | MTBLS13364 | MetaboLights
TranscriptomicsHuman esophageal dysplasia (16 cases) vs. esophageal squamous cell carcinoma (59 cases)
Our aim is to identify frequent genomic aberrations both in ESCC and esophageal dysplasia, and to discover important copy number-driving genes and microRNAs in ESCC. We carried out array-based comparative genomic hybridization (array CGH) on 59 ESCC resection samples and 16 dysplasia biopsy samples....
ORGANISM(S): Homo sapiens 
2013-04-29 | E-GEOD-46452 | biostudies-arrayexpress
ProteomicsHeterozygous variants in MGP lead to endoplasmic reticulum stress causing spondyloepiphyseal dysplasia
Matrix Gla protein (MGP) is a vitamin K-dependent post-translationally modified protein, highly expressed in vascular and cartilaginous tissues. It is a potent inhibitor of extracellular matrix mineralization. Biallelic loss of function variants in the MGP gene cause Keutel syndrome, an autosomal re...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043374 | Pride
Skeletal dysplasia Mgp Spondyloepiphyseal dysplasia 
TranscriptomicsTranscription profiling of human low gestational age newborns as predictors of bronchopleural pulmonary dysplasia
One third to one half of all infants born before the 28th wek of gestation develop BPD bronchopulmonary dysplasia. Our objective is to evaluate the feasibility of using expression profiling in umbilical cord tissue to discover molecular signatures for developmental staging and for risk of BPD. Expe...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8586 | biostudies-arrayexpress
TranscriptomicsMultilineage dysplasia and AML with mutated nucleophosmin
Multilineage dysplasia (MLD) has no impact on biological, clinico-pathological and prognostic features of AML with mutated nucleophosmin (NPM1) NPM1-mutated AML is a provisional entity in the WHO-2008 classification of myeloid neoplasms. The significance of concomitant multilineage dysplasia (MLD) i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-18018 | biostudies-arrayexpress
TranscriptomicsMultilineage dysplasia does not influence prognosis in patients with CEBPA mutated AML supporting the WHO proposal to classify these patients as a unique entity
By WHO 2008, CEBPA-mutated AML became a provisional subentity, but it remains to be clarified how CEBPAmut AML with multilineage dysplasia (MLD; ?50% dysplastic cells in 2-3 lineages) but no other MDS-related feature should be classified. We investigated 108 CEBPAmut AML (15.7-87.6 years) for the im...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-33223 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human liver samples from HCV-induced dysplasia and hepatocellular carcinoma patients, progression study
Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accur...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6764 | biostudies-arrayexpress
TranscriptomicsIdentification of circulating lncRNAs associated with gallbladder cancer risk by tissue-based preselection, cis-eQTL validation, and analysis of association with genotype-based expression
Long non-coding RNAs (lncRNAs) play key roles in cell processes and are good candidates for cancer risk prediction. Few studies have investigated the association between individual genotypes and lncRNA expression. Here we integrate three separate datasets with information on lncRNA expression only, ...
ORGANISM(S): Homo sapiens 
2022-01-17 | E-MTAB-11367 | biostudies-arrayexpress
GenomicsMicrobiome features of bronchopulmonary dysplasia
Microbiome features of bronchopulmonary dysplasia
PRJNA1105631 | ENA
ProteomicsSolute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis
Ulcerative colitis (UC) patients have a greater risk of developing colorectal cancer through inflammation-dysplasia-carcinoma sequence of transformation. The histopathological diagnosis of dysplasia is therefore of critical clinical relevance, but dysplasia may be difficult to distinguish from infla...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD018679 | Pride
Dysplasia associated to inflammation Colorectal neoplasia Label-free proteomics 
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