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TranscriptomicsTranscription profiling of mouse aorta (whole or regions) from mice of different embryonic ages
In order to identify novel regulators of haematopoietic stem cell emergence in the mouse embryonic AGM region, 3 different types of gene expression comparisons were performed. In the first one, whole dorsal aortas from embryonic day (E) 11 embryos and E9 embryos were dissected, tissues from each tim...
ORGANISM(S): Mus musculus 
2009-06-06 | E-TABM-659 | biostudies-arrayexpress
TranscriptomicsAGM hematopoietic stem cells are differentially regulated by BMP and Hedgehog signalling pathways
The first HSCs are produced in the aorta-gonadmesonephros (AGM) region of the embryo through endothelial to a hematopoietic transition. BMP4 and Hedgehog affect their production/expansion, but it is unknown whether they act to affect the same HSCs. In this study using the BRE GFP reporter mouse stra...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-76253 | biostudies-arrayexpress
GenomicsCombinatorial Transcriptional Control in Blood Stem/Progenitor Cells: Genome-wide Analysis of 10 major Transcriptional Regulators
Combinatorial transcription factor (TF) interactions control cellular phenotypes and therefore underpin stem cell formation, maintenance and differentiation. Here we report the genome-wide binding patterns and combinatorial interactions for 10 key regulators of blood stem/progenitor cells (Scl/Tal1,...
ORGANISM(S): Mus musculus 
2010-10-07 | E-GEOD-22178 | biostudies-arrayexpress
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