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GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [RB1_ChIP_2]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59690 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with dl1500 virus (expressing WT small e1a).
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12045 | biostudies-arrayexpress
TranscriptomicsProfiles and ChIP on chip experiments with dl1500 virus (expressing WT small e1a), R2G and deltaCR2 mutant viruses
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-12543 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for knockdown of synthetic lethal gene
We performed genome-wide expression profiling analysis to define the genes underlying the synthetic-lethal relationship between CBP and p300. We extracted 1,936 genes whose expression levels changed >2-fold upon p300-knockdown (KD) in CBP-KO cells, or upon CBP-KD in p300-KO cells, but not in either ...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-73682 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with deltaCR2 mutant virus
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12047 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with R2G mutant virus
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12046 | biostudies-arrayexpress
GenomicsAssessing SMARCA4 restoration contribution to global changes in p300 occupancy in BIN-67 cells
We aim to test how SMARCA4 restoration impacts p300 occupancy distribution. To this aim we generated ChIP-seq samples in BIN-67 with or without A-485 treatment (1 μM, 24h), as a proxy for p300 acetylatransferase inhibition, and BIN-67 with inducible SMARCA4 restoration (1 μg/ml Doxycycline for 24h)....
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15699 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [IMR90_Input]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59692 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [H3k27ac_ChIP]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59680 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [p300_ChIP]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59681 | biostudies-arrayexpress
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