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TranscriptomicsIdentification of genes regulated by glucocorticoids and an RNA binding protein (RBP) in early erythroid progenitor using microarray experiment
Early erythroid progenitors were isolated from mouse E14.5 fetal liver, infected with viruses encoding either control shRNA or shRNAs targeting the RNA binding protein (RBP), and cultured in a medium containing stem cell factor, erythropoietin, and insulin-like growth factor 1, in the absence or pre...
ORGANISM(S): Mus musculus 
2013-06-14 | E-GEOD-46215 | biostudies-arrayexpress
TranscriptomicsExpression data from human CD34+ HPC subpopulations isolated from umbilical cord blood (Haddad et al. Blood 104:3918, 2004)
We used microarrays to analyze the gene expression profile of CD34+CD45RA+CD7+, CD34+CD45RA+CD10+CD19- and CD34+CD45+CD7-CD10-CD19- HPCs isolated from umbilical cord blood CD34+CD45RA+CD7+(CD10-) and CD34+CD45RA+CD10+(CD7-CD19-) HPCs correspond respectively to prothymocytes and early pre-proB precur...
ORGANISM(S): Homo sapiens 
2011-05-25 | E-GEOD-29522 | biostudies-arrayexpress
TranscriptomicsIdentification of transcripts bound by an RNA binding protein (RBP) in early erythroid progenitor using RNA-binding protein immunoprecipitation-microarray (RIP-Chip) experiment
Early erythroid progenitors were isolated from mouse E14.5 fetal liver. After cell lysing, control IgG or RBP specific antibody were incubated with cell lysis. Immunoprecipitation followed by microarray experiments were carried out to identify transcripts that are immunoprecipitated by either contro...
ORGANISM(S): Mus musculus 
2013-06-14 | E-GEOD-46108 | biostudies-arrayexpress
TranscriptomicsRole of glucocorticoids and an RNA binding protein (RBP) in early erythroid progenitors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-14 | E-GEOD-46216 | biostudies-arrayexpress
TranscriptomicsThe transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.
Here we tracked transcriptome changes over ten human hematopoietic stem and early progenitor populations, defining the transcriptional dynamics underlying the first steps of commitment. Most of the transcriptional programs observed extended beyond lineage boundaries. In particular, multi-lymphoid pr...
ORGANISM(S): Homo sapiens 
2013-05-26 | E-GEOD-42414 | biostudies-arrayexpress
GenomicsSingle-cell RNA sequencing of human peripheral blood progenitors captures early mast cell differentiation
Single-cell RNA sequencing of human peripheral blood progenitors captures early mast cell differentiation
PRJNA764206 | ENA
TranscriptomicsSOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B cell development
Here we use a microarray approach to define at the molecular level the consequences of SOX7-mediated effect on B lymphopoiesis and progenitor proliferation. Transcriptome profiling analysis was performed on two subpopulations expressing low and high level of SOX7::GFP. Bone marrow cells extracted fr...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-65552 | biostudies-arrayexpress
TranscriptomicsCXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance
Hematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation, and trafficking. Endosteal osteoblasts and perivascular stromal cells including endothelial cells3, CXCL12-abundant reticular (CAR) cells, leptin-...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43613 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis
mass spectrometry analysis of aged and adult hematopoietic stem cells, multipotent progenitors and oligopotent progenitors
ORGANISM(S): Mus musculus (Mouse) 
2021-07-24 | PXD017442 | Pride
Hematopoiesis Early blood progenitors Stem cells Hematopoietic stem cells Aging 
GenomicsSingle cell transcriptomic of ex vivo-generated lymphoid progenitors from mobilised peripheral blood- or corb blood-derived hematopoietic stem and progenitors cells
Single cell transcriptomic of ex vivo-generated lymphoid progenitors from mobilised peripheral blood- or corb blood-derived hematopoietic stem and progenitors cells
PRJNA1241729 | ENA
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