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GenomicsBivalent Chromatin Marks Developmental Regulatory Genes in the Mouse Embryonic Germline in Vivo
We developed a ChIP protocol for the analysis of histone marks using less than 10,000 cells per IP, and used it to investigate the chromatin state of E11.5 mouse primordial germ cells (PGCs). A genome-wide ChIP-Seq analysis of E11.5 PGCs revealed a distribution of H3K4me3/H3K27me3 bivalent domains h...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46396 | biostudies-arrayexpress
UnknownPatient-driven discovery and post-clinical validation of NTRK3 fusion as an acquired resistance mechanism to selpercatinib in RET fusion-positive lung cancer.
Not available
S-EPMC8119360 | biostudies-literature
GenomicsVitamin C induces Tet-dependent DNA demethylation in ES cells to promote a blastocyst-like methylome [MeDIP-Seq]
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germline and may be mediated by Tet (ten-eleven-translocation) enzymes, which convert 5-methylcytosine (...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-46402 | biostudies-arrayexpress
TranscriptomicsVitamin C induces Tet-dependent DNA demethylation in ES cells to promote a blastocyst-like methylome [Affymetrix]
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germline and may be mediated by Tet (ten-eleven-translocation) enzymes, which convert 5-methylcytosine (...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-46319 | biostudies-arrayexpress
Genomics4dbf9af0-d667-494b-b3d9-c80c112d0527 - samples
high depth WGS sequencing of 8 sites of a RET fusion tumour
EGAD00001006878 | EGA
Genomicsdc7d6e29-28d7-43ec-895c-d530c18112cf - samples
Deep WGS sequencing (160x) of 2 different sites of disease of a patient with a RET fusion positive cancer. Amplicon sequencing of 19 other sites of the same patients for the RET fusion.
EGAD00001005776 | EGA
GenomicsMulti-regional tumour biopsies of a RET fusion patient
Identifying modes of resistance to a new experimental drug for a patient resistant to other therapies
EGAS00001004023 | EGA
GenomicsPeter MacCallum Cancer Centre Research Data Access Committee
Data Access Committee EGAC00001001404
EGAC00001001404 | EGA
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