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TranscriptomicsComparison of H111 c3-null mutants R12 and R33 to wild-type
The purpose of this experiment was to determine differences in expression between wild-type B. cenocepacia H111 and two Tn5 mutants, R12 and R33, isolated during a Tn-mutagenesis screen for reduced pathogenicity.
ORGANISM(S): Burkholderia cenocepacia 
2012-07-11 | E-MTAB-732 | biostudies-arrayexpress
TranscriptomicsThe IclR-family regulator BapR controls biofilms formation in B. cenocepacia H111
In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that Quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify a protein from...
ORGANISM(S): Burkholderia cenocepacia H111 
2014-03-26 | E-GEOD-52769 | biostudies-arrayexpress
TranscriptomicsThe AHL- and BDSF-dependent quorum sensing systems control specific and overlapping sets of genes in Burkholderia cenocepacia H111
Quorum sensing in Burkholderia cenocepacia H111 involves two signalling systems that depend on different signal molecules, namely N-acyl homoserine lactones (AHLs) and the diffusible signal factor cis-2-dodecenoic acid (BDSF). Previous studies have shown that AHLs and BDSF control similar phenotypic...
ORGANISM(S): Burkholderia cenocepacia H111 
2012-11-01 | E-GEOD-41244 | biostudies-arrayexpress
TranscriptomicsMapping the quorum sensing regulon of Burkholderia cenocepacia H111
Comparative transcriptional profiling of the Burkholderia cenocepacia H111 wild type, the cepR mutant H111-R and the complemented cepR mutant H111-R (pBAH27).
ORGANISM(S): Burkholderia cenocepacia 
2011-05-01 | E-MTAB-509 | biostudies-arrayexpress
ProteomicsP.aeruginosa - Whole organism, Biofilm, SC (Toyofuku,j_proteome_res,2012)
abundance based on Spectral counting, biofilm, Interaction consistency score: 7.2, Coverage: 31
ORGANISM(S): 208964 
2012-00-00 | 1231515390 | PAXDB
TranscriptomicsTranscription profiling of B. cenocepacia K56-2 wildtype and cepR2 mutant
Comparative transcriptional profiling of B. cenocepacia K56-2 (wildtype) and K56-2cepR2b (cepR2 mutant of K56-2).
ORGANISM(S): Burkholderia cepacia 
2009-02-10 | E-MEXP-1935 | biostudies-arrayexpress
TranscriptomicsResponse of Burkholderia cenocepacia H111 to micro-oxia
B. cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering from cystic fibrosis (CF). In the CF lung, bacteria grow to high densities within the viscous mucus that is limited in oxygen. Pseudomonas aeruginosa, the dominant pathogen in CF patients, is kn...
ORGANISM(S): Burkholderia cenocepacia H111 
2013-07-15 | E-GEOD-48585 | biostudies-arrayexpress
ProteomicsThanatin Targets the Inter-Membrane Protein Complex Required for Lipopolysaccharide Transport in Escherichia coli
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest here are the proteins required for the biogenesis of the symmetric Gram-negative bacterial out...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084897 | MassIVE
Transcriptomicss54 -dependent response to nitrogen limitation and virulence in Burkholderia cenocepacia H111
Members of the genus Burkholderia are versatile bacteria capable of colonizing highly diverse environmental niches. In this study, we investigated the global response of the opportunistic pathogen Burkholderia cenocepacia H111 to nitrogen limitation at the transcript and protein expression level. In...
ORGANISM(S): Burkholderia cenocepacia H111 
2015-04-29 | E-GEOD-66328 | biostudies-arrayexpress
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
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