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ProteomicsSignal sequence characteristics of periplasm and thylakoid lumen proteins in cyanobacteria revealed using a proximity-based proteomics generated spatial proteome
Cyanobacteria have an inner and outer cell membrane enclosing the periplasm and cell wall and an additional set of membranes called the thylakoid membranes enclosing thylakoid lumen. The periplasm and thylakoid lumen have unique proteomes, but the mechanisms sorting proteins to these locations have ...
ORGANISM(S): Synechococcus sp. PCC 7002 x Microcystis aeruginosa TAIHU98 coculture 
2026-02-09 | PXD058004 | Pride
Signal sequence Cyanobacteria Protein localization Apex2 Proximity-based proteomics 
ProteomicsTaf2 mediates DNA binding of Taf14
The assembly and function of the yeast general transcription factor TFIID complex requires specific contacts between its Taf14 and Taf2 subunits, however, the mechanism underlying these contacts remains unclear. Here, we determined the molecular and structural basis by which the YEATS and ET domains...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD033397 | Pride
Taf2 mediates dna binding of taf14 
ProteomicsSystematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II Pre-Initiation Complex (PIC), TFIIH regulates pol II enzyme activity in numerous ways. The TFIIH subunit XPB/Ssl2 is an ATP-de...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD036107 | Pride
Tfiih p52/tfb2 xpb/ssl2 tfb6 
ProteomicsCooperative polarization of MCAM/CD146 and ERM family proteins in melanoma
The WRAMP structure is a protein network associated with tail-end actomyosin contractility, membrane retraction, and directional persistence during cell migration. A marker of WRAMP structures is melanoma cell adhesion molecule (MCAM) which dynamically polarizes to the cell rear. However, factors th...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047722 | Pride
Wnt5a Wramp Mcam Erm 
ProteomicsMyocardial recovery with mechanical circulatory support is linked to alternative splicing and subcellular localization of CAMK2D
Cardiac reverse remodeling occurs in a small subset of heart failure patients treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) ther...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD068397 | Pride
Lvad proteomics 
ProteomicsMyocardial recovery with mechanical circulatory support is linked to alternative splicing and subcellular localization of CAMK2D
Cardiac reverse remodeling occurs in a small subset of heart failure patients treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) ther...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-12 | PXD068395 | Pride
Lvad phospho-proteomics 
ProteomicsMyocardial recovery with mechanical circulatory support is linked to alternative splicing and subcellular localization of CAMK2D
Cardiac reverse remodeling occurs in a small subset of heart failure patients treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) ther...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD068672 | Pride
Human lvad phospho-proteomics 
ProteomicsDigital Light Processing 3D Printing Enables Versatile Fabrication of Human Engineered Heart Tissues
While cell models are routinely used to study cardiac molecular biology, in vitro systems fall far short of mimicking the metabolic and sarcomere structural maturity of intact cardiac tissue. Achieving a mature cardiomyocyte (CM) phenotype is essential for creating a physiologically relevant environ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD074288 | Pride
Human engineered heart tissues Digital light processing 
ProteomicsMORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
Human acetyltransferases MOZ and MORF are implicated in chromosomal translocations associated with aggressive leukemias. Oncogenic translocations involve the far amino terminus of MOZ/MORF, the function of which remains unclear. Here, we identified and characterized two structured winged helix domai...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036192 | Pride
Morf moz cpg islands 
ProteomicsIdentification of RNA chaperones by gradient profiling in the Lyme disease spirochete, Borrelia burgdorferi
RNA-binding proteins (RBPs) play key roles in regulating gene expression in bacteria. However, relatively few RBPs have been discovered and characterized in Borrelia (Borreliella) burgdorferi, the causative agent of Lyme disease. We utilized gradient profiling to identify putative RBPs that co-sedim...
ORGANISM(S): Borreliella burgdorferi 
2026-06-29 | PXD068462 | Pride
Lyme disease Borrelia burgdorferi Rna chaperone Rna-binding protein 
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