Sort   by:  
 Page size 
GenomicsGenome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells
We apply cellular reprogramming to an induced pluripotent cell state to human cell lines and primary samples exhibiting Chronic Myoloid Leukemia (CML). Addtionally, we generated an inducible CML BCR-ABL transgenic mouse model. Biological replicates (duplicates) were available for all samples. DNA me...
ORGANISM(S): Homo sapiens 
2015-07-14 | E-GEOD-50456 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls
Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their l...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-21606 | biostudies-arrayexpress
TranscriptomicsRIPSEQ DNMT1 HL60
Identification of the all RNA species associated with DNMT1. Using a comparative genome-scale approach we identified and correlated the RNA species physically associated with DNMT1 and proximal to the annotated genes to the methylation status of the corresponding loci and expression levels of the re...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-32162 | biostudies-arrayexpress
GenomicsGenome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells (sequencing)
We analyzed the methylation pattern of a well characterized leukemia cell line, named K562. Furthermore, we decided to investigate how the malignant epiegenome change during the reprogramming process We used RRBS analysis to investigate the methylation pattern in leukemia and reprogrammed leukemia (...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-33230 | biostudies-arrayexpress
TranscriptomicsGenome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells (gene expression)
We analyzed the methylation pattern of a well characterized leukemia cell line, named K562. Furthermore, we decided to investigate how the malignant epiegenome change during the reprogramming process We used Affymatrix expression microarrays analysis to investigate the relation between expression an...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-33226 | biostudies-arrayexpress
GenomicsRRBS (Reduced Representation Bisulfite Sequencing) of HL60
We exploited the methylation genome-scale screening RRBS to correlate the RNA species physically associated with DNMT1 and proximal to the annotated genes to the methylation status of the corresponding loci. Out of 15275 non ambiguous gene loci identified by DNMT1 RIP-Seq, 9436 loci were covered by ...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-32168 | biostudies-arrayexpress
TranscriptomicsRNA-seq HL60 cells
Identification of the all RNA species coding and non-coding in total RNA Relationship between DNMT1-RNA interactions, DNA methylation and gene expression
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41279 | biostudies-arrayexpress
TranscriptomicsExpression data from WT HL60 cells
We used the microarray analysis to detail the gene expression profile from the leukemic cell line HL-60 Relationship between DNMT1-RNA interactions, DNA methylation and gene expression
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-32153 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hematopoietic stem cells in the preleukemic phase from wiltype mice and mice deficient in transcription factor PU.1 to identify transcriptional changes preceding malignant transformation
Knockdown of the transcription factor PU.1 (Spi1) leads to acute myeloid leukemia (AML) in mice. We examined the transcriptome of PU.1 knockdown hematopoietic stem cells (HSC) in the preleukemic phase by linear amplification and genome-wide array analysis to identify transcriptional changes precedin...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5654 | biostudies-arrayexpress
GenomicsSox4 is a key oncogenic target in C/EBPa mutant Acute Myeloid Leukemia
Mutation or epigenetic silencing of the transcription factor C/EBPa is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-50565 | biostudies-arrayexpress
Sort   by:  
 Page size