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TranscriptomicsGlobal gene expression profiles in Oct4-knockdown and Ccna2-knockdown mouse embryos.
Gene regulation at the maternal-embryonic transition in the pre-implantation mouse embryo is not well understood. We knock down Ccna2 to establish proof-of-concept that antisense morpholino oligonucleotides can be used to target specific genes. We applied this strategy to study Oct4 and discovered...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-13981 | biostudies-arrayexpress
ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
TranscriptomicsTranscription profiling of human heart with heart failure due to ischemic cardiomyopathy or dilated cardiomyopathy
End stage heart failure due to ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) have similar characteristics, enlargement of the ventricles, relatively thin-walled ventricle, which leads to a limited contraction force and blood loading. Nevertheless, the response for present therapeuti...
ORGANISM(S): Homo sapiens 
2007-10-31 | E-CVDE-1 | biostudies-arrayexpress
UnknownBDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
Not available
S-JCBD-201201038 | bioimages
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
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