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ProteomicsThe assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA facilitates CI assembly, and how it is linked with AD pathog...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-12-13 | PXD042905 | Pride
Keywords: oxidative phosphorylation (oxphos) Mitochondrial complex i assembly complex (mcia) Fatty acid oxidation (fao) Amyloid-β Ecsit phosphorylation Cryo-em 
UnknownECSIT is a critical limiting factor for cardiac function.
Not available
S-EPMC8262467 | biostudies-literature
UnknownECSIT-X4 is Required for Preventing Pressure Overload-Induced Cardiac Hypertrophy via Regulating Mitochondrial STAT3.
Not available
S-EPMC11848529 | biostudies-literature
ProteomicsThe structural mechanism of MCIA complex assembly links mitochondrial redox pathways
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA facilitates CI assembly, and how it is linked with AD pathog...
ORGANISM(S): Escherichia coli 
2023-12-13 | PXD042858 | Pride
Oxidative phosphorylation (oxphos) Mitochondrial complex i assembly complex (mcia) Fatty acid oxidation (fao) Amyloid-β Ecsit phosphorylation Cryo-em 
UnknownImpaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.
Not available
S-EPMC9652319 | biostudies-literature
UnknownThe assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination.
Not available
S-EPMC10716376 | biostudies-literature
UnknownAssembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination.
Not available
S-EPMC7986633 | biostudies-literature
ProteomicsDissecting the Roles of Mitochondrial Complex I Intermediate Assembly (MCIA) Complex Factors in the Biogenesis of Complex I
Mitochondrial Complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its biogenesis requires the assembly and integration of distinct intermediate modules, mediated by numerous assembly factors. The Mitochondrial Complex I Intermediate Assembly (MCIA) complex, containing assembly factors...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018075 | Pride
Assembly factors Mitochondria Nadh-ubiquinone dehydrogenase Mcia complex Complex i Oxidative phosphorylation 
UnknownProteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation.
Not available
S-EPMC9093983 | biostudies-literature
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