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We performed whole genome sequencing of tumor and normal DNA samples obtained from 22 infant ALL cases with MLL rearrangements. In addition, we sequenced 2 paired diagnostic-relapse samples. Using complementary pipelines, somatically acquired genetic changes were analyzed, including single nucleotid...
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DATA FILES FOR PCGP SJINF WES
Hypodiploid acute lymphoblastic leukemia whole genome sequencing
DATA FILES FOR SJINF RNASeq
DATA FILES FOR SJPHALL
DATA FILES FOR SJINF
PCGP INF ALL SNP6
DATA FILES FOR BALL-PAX5
Hypodiploid acute lymphoblastic leukemia (ALL) is an aggressive leukemia characterized by aneuploidy and poor outcome. The genetic basis of hypodiploid ALL is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two subtypes that differ in the s...
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