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MetabolomicsMetabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival

The spread of cancer to bone is invariably fatal, with complex cross-talk between tumor cells and the bone microenvironment responsible for driving disease progression. By combining in silico analysis of patient datasets with metabolomic profiling of prostate cancer cells cultured with bone cells...

2024-08-19 | MTBLS3973 | MetaboLights
TranscriptomicsG-CSF receptor targeting in inflammatory arthritis
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. We developed a neutralizing monoclonal antibody to the murine G-CSF receptor (G-CSFR), which antagonizes binding of murine G-CSF and inhibits G-CSFR signallin...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-76966 | biostudies-arrayexpress
ProteomicsConsequences of aneuploidy in human fibroblasts
To characterize aneuploidy driven phenotypes in human trisomies, we performed global transcriptome, proteome, and phenotypic analysis of primary human fibroblasts from individuals with Patau (trisomy 13), Edwards (trisomy 18), or Down syndromes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-09 | MSV000085706 | MassIVE
GenomicsGenome-wide methylation and expression analysis of two breast cancer cell lines [Methyl-MAPS]
To improve our understanding of the relationships between methylation and expression we profiled mRNA expression and single-base resolution methylation levels for two breast cancer cell lines, MCF7 and T47D. Expression was profiled using RNA-seq. Methylation was assayed using Methyl-MAPS, which use...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-45336 | biostudies-arrayexpress
TranscriptomicsMurine Schistosoma-Induced Pulmonary Hypertension: RNA-seq Data
Whole lung RNA-seq of 8 mice with experimental Schistosoma-induced pulmonary hypertension, compared to 8 control mice. All mice on a C57Bl6/J background. 3 schisto-PH and 3 control mice (#s 1-3 in each group) were also processed by Affy microarray and separately submitted. 3 of the mice in each grou...
ORGANISM(S): Mus musculus 
2013-07-23 | E-GEOD-49114 | biostudies-arrayexpress
UnknownReal-world 6-month outcomes of minimally invasive aortic valve replacement with the EDWARDS INTUITY Elite valve system.
Not available
S-EPMC9631962 | biostudies-literature
UnknownConventional versus rapid-deployment aortic valve replacement: a single-centre comparison between the Edwards Magna valve and its rapid-deployment successor.
Not available
S-EPMC4986793 | biostudies-literature
UnknownEight-year outcomes of aortic valve replacement with the Carpentier-Edwards PERIMOUNT Magna Ease valve.
Not available
S-EPMC10100054 | biostudies-literature
UnknownStabilized G protein binding site in the structure of constitutively active metarhodopsin-II.
Not available
S-EPMC3252945 | biostudies-literature
UnknownA Bayesian approach to the g-formula.
Not available
S-EPMC5790647 | biostudies-literature
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