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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
TranscriptomicsGlobal Transcriptional Analysis of Mycoplasma hyopneumoniae Following Exposure to Norepinephrine
The goal of this study is to gain a better understanding of the transcriptional responses of M. hyopneumoniae under norepinephrine stress. Six independent RNA samples from norepinephrine-exposed cultures were paired with six independent RNA samples from control cultures for hybridization to six two-...
ORGANISM(S): Mycoplasma hyopneumoniae 
2010-05-26 | E-GEOD-8494 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal muscles from young, old, and old calorie restricted C57BL/6NHsd mice to investigate age-related changes in the transcriptional profile
We investigated age-related changes in the transcriptional profile of skeletal muscle in 5 month old (young) and 25 month old (old) C57BL/6NHsd mice using high density oligonucleotide arrays (22,690 transcripts probed). We identified 712 transcripts that are differentially expressed in young (5 mon...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-6323 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of gonadotrope pituitary tumors identifies Growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a Novel Tumor Suppressor in Pituitary Gonadotrope Tumors
Gonadotrope or null cell pituitary tumors present clinically with signs of hypogonadism and hypopituitarism, together with visual disturbances due to mass effects. Since there are no medical therapies, surgery and/or radiation are the only therapeutic options. To identify dysregulated genes and/or...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26966 | biostudies-arrayexpress
UnknownUse of Moraxella catarrhalis lipooligosaccharide mutants to identify specific oligosaccharide epitopes recognized by human serum antibodies.
Not available
S-EPMC2747917 | biostudies-literature
UnknownElevated temperature drives kelp microbiome dysbiosis, while elevated carbon dioxide induces water microbiome disruption.
Not available
S-EPMC5825054 | biostudies-literature
UnknownCovalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.
Not available
S-EPMC4506735 | biostudies-literature
MetabolomicsUntargeted metabolomics analyses and contaminant chemistry of Dreissenid mussels at the Maumee River Area of Concern in the Great Lakes

Bivalves serve as an ideal ecological indicator; hence, their use by the NOAA Mussel Watch Program to monitor environmental health. This study aimed to expand the baseline knowledge of using metabolic end points in environmental monitoring by investigating the dreissenid mussel metabolome in the ...

2024-06-03 | MTBLS6311 | MetaboLights
UnknownFractal dimension of the aortic annulus: a novel predictor of paravalvular leak after transcatheter aortic valve implantation.
Not available
S-EPMC9700572 | biostudies-literature
TranscriptomicsApplication of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions
Chromosomal instability is central to the process of carcinogenesis. The detection of somatic chromosomal alterations in small premalignant lesions genome-wide remains challenging since sample heterogeneity dilutes the aberrant cell information. We introduced an analytic metric termed "delta-θ&...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-43168 | biostudies-arrayexpress
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