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Cancer associated fibroblasts characterized by an myofibroblastic phenotype play a major role in the tumour microenvironment, being associated with poor prognosis. We found that this cell population is made in part by senescent fibroblasts in vivo. As senescent fibroblasts and myofibroblasts have be...
ORGANISM(S): Homo sapiens 
The human KRT12 gene, carrying a dominant-negative mutation was knocked into the murine Krt12 locus by gene targeting in mouse embryonic stem cells, which were subsequently used to generate transgenic mice on the C57BL/6 background. mRNA gene expression changes were determined in wild type, heterozy...
ORGANISM(S): Mus musculus 
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