Sort   by:  
 Page size 
MetabolomicsHuman Milk-Derived 5′-UMP Promotes Thermogenesis and Mitochondrial Biogenesis to Ameliorate obesity

Background: Traditional obesity interventions are often unsuitable for children. Breastfeeding has been shown to reduce obesity risk, potentially through bioactive metabolites in human milk. Here, we identified a human milk-derived metabolite, uridine 5'-monophosphate (5'-UMP), whose role in lipi...

2025-09-23 | MTBLS13027 | MetaboLights
ProteomicsMS data for Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis
Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. It is not clear how this promiscuous mechanism ensure efficient production of challenging clients such as highly expressed proteins. Here we find that the biogenesis of the abund...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-16 | PXD043391 | Pride
Ribosome-associated chaperone Hsf1 activation Eef1a biogenesis 
GenomicsDedicated chaperone at the ribosome safeguards the proteostasis network during eEF1A biogenesis
Dedicated chaperone at the ribosome safeguards the proteostasis network during eEF1A biogenesis
PRJNA915314 | ENA
TranscriptomicsDedicated chaperone at the ribosome safeguards the proteostasis network during eEF1A biogenesis
Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. Here we find that the universal cotranslational machinery adapts to accommodate the challenging biogenesis of abundantly expressed eukaryotic translation elongation factor 1A (eE...
ORGANISM(S): Saccharomyces cerevisiae 
2024-01-16 | GSE221651 | GEO
UnknownChp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis.
Not available
S-EPMC10869706 | biostudies-literature
UnknownZinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis.
Not available
S-EPMC10016025 | biostudies-literature
UnknownA ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A.
Not available
S-EPMC11790920 | biostudies-literature
UnknownTargeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response.
Not available
S-EPMC2967282 | biostudies-literature
ProteomicsYpl225w-3xFLAG IP-mass spectrometry
Eukaryotic translation elongation factor 1A (eEF1A) is a highly abundant, multi-domain GTPase. Post-translational steps essential for eEF1A biogenesis are carried out by bespoke chaperones but co-translational mechanisms tailored to eEF1A folding remain unexplored. Here, we find that the N-terminal,...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2025-02-05 | PXD058955 | Pride
Yeast Ypl225w 
UnknownDefining functional interactions during biogenesis of epithelial junctions.
Not available
S-EPMC5150262 | biostudies-literature
Sort   by:  
 Page size