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MetabolomicsDifferential alteration of plant functions by homologous fungal candidate effectors

Rust fungi are plant pathogens that cause epidemics which threatens the production of many important plant species, such as wheat, soy, coffee and poplar. Melampsora larici-populina (Mlp) causes the poplar rust and encodes at least 1184 candidate effectors (CEs), however their functions are poorl...

2020-12-03 | MTBLS2096 | MetaboLights
TranscriptomicsComparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice
We have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed during leptin receptor deficiency, which is partly responsible for the inhibition of T cell effector functions. Mouse CD4+CD25- T cells were purified from leptin-receptor-...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29607 | biostudies-arrayexpress
GenomicsGlobal DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function
In response to acute infection CD8 T cells differentiate into effector cells capable of clearing the antigen. While the transcriptional and functional changes have previously been studied little is known of the epigenetic modifications that accompany this differentiation process. To gain insights ...
ORGANISM(S): Mus musculus 
2013-08-18 | E-GEOD-44638 | biostudies-arrayexpress
GenomicsSystematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
PRJNA1482054 | ENA
TranscriptomicsGene expression profiles of effector T cells induced by mTOR inhibition
To further develop our gene expression approach to treatment of autoimmunity, we have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed upon immunosuppressor treatment responsible for inhibition of T cell effector functions. Huma...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-29606 | biostudies-arrayexpress
TranscriptomicsCharacterization of A Novel CRAC Inhibitor that Potently Blocks Human T cell Activation and Effector Functions
Store operated calcium entry (SOCE) downstream of T cell receptor (TCR) activation in T lymphocytes has been shown to be mediated mainly through the Calcium Release Activated Calcium (CRAC) channel. Here, we compared the effects of a novel, potent and selective CRAC inhibitor, 2,6-Difluoro-N-{5-[4-m...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43210 | biostudies-arrayexpress
TranscriptomicsGene expression in LCMV-specific Blimp-1 deficient effector CD8+ T cells compared to wildtype effector CD8+ T cells
Antigen-specific effector CD8+ T cells deficient in Blimp-1 (Prdm1) do not acquire maximal effector functions, evade terminal differentiation, and more rapidly acquire some hallmark properties of memory CD8+ T cells. In this study, we compared the gene expression profiles of wildtype and Prdm1-/- LC...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17211 | biostudies-arrayexpress
GenomicsMemory-like natural killer cells facilitate effector functions of daratumumab in multiple myeloma
Memory-like natural killer cells facilitate effector functions of daratumumab in multiple myeloma
PRJNA658903 | ENA
GenomicsT cell receptor-triggered nuclear actin network formation drives CD4 T cell effector functions
T cell receptor-triggered nuclear actin network formation drives CD4 T cell effector functions
PRJNA505494 | ENA
GenomicsThe role of b2-integrins for the effector functions of polymorphonuclear granulocytes
The role of b2-integrins for the effector functions of polymorphonuclear granulocytes
PRJNA800683 | ENA
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