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ClinicalA Study to Evaluate eFT508 Alone and in Combination With Avelumab in Subjects With MSS Colorectal Cancer
This is a Phase 2, open-label, 2-part, multicenter study in subjects with MSS relapsed/refractory colorectal cancer. The primary objective of Part 1 is to evaluate the safety and tolerability of escalating doses of eFT508 in combination with a fixed dose of avelumab to determine the maximum tolerate...
2252459 | ecrin-mdr-crc
UnknownA Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice.
Not available
S-EPMC8116363 | biostudies-literature
OtherTranslation efficiency in the pancreatic tumor in response to ketogenic diet and targeting eIF4E phosphorylation
To investigate the translatome in the pancreatic tumor inresponse to ketogenidc diet and the combination of ketogenic diet with an inhibitor targeting eIF4E phosphorylation. We generated pancreatic tumor xenograftmice model, treated mice with regular chow, ketogenic diet or ketogenic diet with eFT50...
ORGANISM(S): Homo sapiens 
2024-08-14 | GSE267398 | GEO
UnknownTomivosertib reduces ectopic activity in dorsal root ganglion neurons from patients with radiculopathy.
Not available
S-EPMC11370786 | biostudies-literature
TranscriptomicsNociceptor translational profiling reveals the RagA-mTORC1 network as a critical generator of neuropathic pain
Pain sensing neurons, nociceptors, are key drivers of neuropathic pain. We used translating ribosome affinity purification (trap) to comprehensively characterize up- and down-regulated mRNA translation in Scn10a-positive nociceptors in chemotherapy-induced neuropathic pain. We provide evidence that ...
ORGANISM(S): Mus musculus 
2018-08-01 | GSE113941 | GEO
UnknownNociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.
Not available
S-EPMC6335757 | biostudies-literature
UnknownThe Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells.
Not available
S-EPMC11331482 | biostudies-literature
UnknownmRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
Not available
S-EPMC8262354 | biostudies-literature
GenomicsTranscriptional profiling of intestinal changes in Apc Kras tumours with MYC activation and/or drug combination treatment
Transcriptional profiling of intestinal changes in Apc Kras tumours with MYC activation and/or drug combination treatment
PRJNA668925 | ENA
UnknownTranslation control of the immune checkpoint in cancer and its therapeutic targeting.
Not available
S-EPMC6613562 | biostudies-literature
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