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TranscriptomicsMicroarray analysis of WT and Tfap4-KO CD8 T cells during early activation
Gene expression of Tfap4–/– and WT CD8+ T cells were compared after activation with anti-CD3 and anti-CD28 antibodies in vitro or with Listeria monocytogenes infection in vivo For in vitro activation, naive CD8+ T cells were purified from WT and Tfap4–/– mice and activated with anti-CD3 and ...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58078 | biostudies-arrayexpress
ProteomicsThe interactomes of RUNX1 and RUNX3 from Mus musculus T cells
Cellular binary fate decisions require the progeny to silence genes associated with the alternative fate. The major subsets of alpha:beta T cells have been extensively studied as a model system for fate decisions. While the transcription factor RUNX3 is required for the initiation of Cd4 silencing i...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD007511 | Pride
Mus musculus runx1 runx3 immunoprecipitation t cells 
TranscriptomicsHDAC1/2 and CD4+ T cells
Dynamic changes in histone acetylation patterns are mediated by the activity of histone acetyltransfereases (HATs) and histone deacetylases (HDACs) and are key events in the epigenetic regulation of gene expression. The application of HDAC inhibitors revealed a variety of T cell functions controlled...
ORGANISM(S): Mus musculus 
2014-03-30 | E-MTAB-2184 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the effects of IL-2 signaling on in vitro activated WT CD8 T cells
Interleukin 2 (IL-2) promotes proliferation and differentiation of CD8+ T cells in vitro and in vivo. To define gene expression regulated by IL-2, we purified naive CD8+ T cells, activated them for 2 days followed by treatment with recombinant IL-2 or with neutralizing antibody against IL-2 and com...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58077 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of cMyc-deficient CD8 T cells retrovirally overexpressing cMyc or AP4
To determine functional overlap between cMyc and AP4 in CD8+ T cell priming, we retrovirally expressed cMyc or AP4 in cMyc-deficient CD8+ T cells and examined gene expression after activation. Naive CD8+ T cells from Myc conditional knockout mice with a tamoxifen inducible Cre transgene were retrovi...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58079 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Myc, AP4, and phosphorylated RNA polymerase II binding in activated CD8 T cells by ChIP sequencing
The trasncription factor cMyc is an essential transcription factor that establishes a metabolically active and proliferative state in T cells after antigen priming. However, its expression is transient. To date, it remains unknown how T cell activation is maintained after cMyc down-regulation. Here,...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58075 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in CD8+ T cells activated in vitro or in vivo
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58081 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of thymocyte subsets
Mouse thymocytes can be classified into four major subsets based on expression of CD4 and CD8 co-receptors. CD4-CD8- (double negative, DN) cells become CD4+CD8+ (double positive, DP) cells following productive T cell receptor (TCR) beta chain rearrangement. A small proportion of DP cells are selecte...
ORGANISM(S): Mus musculus 
2011-08-09 | E-GEOD-31082 | biostudies-arrayexpress
TranscriptomicsDefining AP4- and MYC-regulated gene expression programs in germinal center B cells during cyclic re-entry
B cells diversify and affinity-mature their antigen receptor repertoire in germinal centers (GC). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions sustain the subsequent proliferative program of selected B cells. H...
ORGANISM(S): Mus musculus 
2016-08-23 | E-GEOD-80669 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of WT and Tfap4–/– OT-I cells activated by Listeria monocytogenes expressing ovalbumin
Gene expression of Tfap4–/– and WT OT-I T cells were compared 4 or 6 days after activation with Listeria monocytogenes infection in vivo with the ERCC spike-in RNA control. Naive CD8+ T cells from Tfap4–/– OT-I or control WT OT-I TCR transgenice mice were adoptively transferred to congenic host mice...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58076 | biostudies-arrayexpress
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