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ProteomicsSecretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation
EGF domains of human NOTCH3 were prepared from HEK293T cells.
ORGANISM(S): Homo Sapiens (human) 
2024-07-27 | PXD035703 | JPOST Repository
ProteomicsPOGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of FBN1
Fibrillin-1 (FBN1) is the major component of extracellular matrix microfibrils, which are required for proper development of elastic tissues including heart and lung. Through protein-protein interactions with latent TGF-beta binding protein 1 (LTBP1), microfibrils assist regulation of TGF-beta signa...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD025725 | Pride
Extracellular matrix protein Egf repeats Mass spectrometry Glycosylation Protein secretion Protein folding 
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
UnknownSite-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats.
Not available
S-EPMC3464504 | biostudies-literature
UnknownNotch Missense Mutations in Drosophila Reveal Functions of Specific EGF-like Repeats in Notch Folding, Trafficking, and Signaling.
Not available
S-EPMC9775759 | biostudies-literature
UnknownEfficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1.
Not available
S-EPMC10935072 | biostudies-literature
UnknownGrowth control by EGF repeats of the C. elegans Fibulin-1C isoform.
Not available
S-EPMC1747532 | biostudies-literature
UnknownPOGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.
Not available
S-EPMC8405936 | biostudies-literature
UnknownO-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals.
Not available
S-EPMC5388531 | biostudies-literature
ProteomicsComprehensive O-GlcNAc glycoproteomics on NOTCH1 EGF repeats refined the sequons for O-GlcNAcylation and uncovered unique Lewis X epitopes in mammals
This study performed the comprehensive mass spectrometric analyses of O-GlcNAc glycans on NOTCH1 in mammalian cultured cells. The results indicated that the O-GlcNAcylation occurs only a subset of EGF repeats harboring putative O-GlcNAcylation sites, refining the sequons for extracellular O-GlcNAcyl...
ORGANISM(S): Mus Musculus (mouse) 
2020-11-03 | PXD022305 | JPOST Repository
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