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GenomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (ChIP-Seq)
We studied the chromatin modification patterns induced by the presence of the MLL-AF9 fusion protein in a model of human hematopoietic stem/progenitor cells (HSPC) transduced with retrovirus expressing MLL-AF9cDNA (HSPC-MA9). Comparative ChIP-seq analysis between HSPC-MA9 and control HSPC, revealed ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54344 | biostudies-arrayexpress
TranscriptomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (microarray)
We investigated the response of acute myeloid cells (AML) expressing MLL-AF9 fusion gene to the pan-HDACi panobinostat (LBH589), and found that low conentrations of panobinostat lead to MLL-AF9 cell toxicity and rapid changes in gene expression. Human hematopoietic stem/progenitor cells (HSPC) expre...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54218 | biostudies-arrayexpress
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