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MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
ProteomicsToxoplasma gondii eIF-5A knockdown iTraq
Proliferative stage (tachyzoite) is a critical factor in the transmission and pathogenesis of Toxoplasma gondii (T. gondii), which is capable of infecting a large variety of host cells. Proto-oncogene eukaryotic translation initiation factor (eIF-5A) is thought to function in regulation of many cell...
ORGANISM(S): Toxoplasma gondii RH 
2021-09-09 | PXD016810 | Pride
Toxoplasma gondii Itraq 
GenomicsseCLIP of C. elegans EIF-3.G in the cholinergic motor neurons
seCLIP of C. elegans EIF-3.G in the cholinergic motor neurons
PRJNA640155 | ENA
TranscriptomicsTranscriptional and translational effect of the lack of translation initiation factor eIF(iso)4E
One of the most regulated steps of translation initiation is the recruitment of an mRNA by the translation machinery. In eukaryotes, this step is mediated by the 5M-BM-4end cap-binding factor eIF4E bound to the bridge protein eIF4G and forming the eIF4F complex. In plants, different isoforms of eIF4...
ORGANISM(S): Arabidopsis thaliana 
2013-07-26 | E-GEOD-29386 | biostudies-arrayexpress
TranscriptomicsseCLIP of C. elegans EIF-3.G in the cholinergic motor neurons
Protein translation is tightly regulated at the initiation phase, which entails exceedingly complex interactions among multiple EIF initiation factors to bring the ribosome to the mRNA and scan the 5’ leader sequence for the start codon. EIF-3 contains multiple subunits with essential and emerging r...
ORGANISM(S): Caenorhabditis elegans 
2021-08-18 | GSE152704 | GEO
UnknownCausal association between mTOR-dependent EIF-4E and EIF-4A circulating protein levels and type 2 diabetes: a Mendelian randomization study.
Not available
S-EPMC7519073 | biostudies-literature
TranscriptomicseIF3a in Urinary Bladder Cancer M-bM-^@M-^S in vivo and in vitro insights
The eukaryotic translation initiation factor (eIF) 3a is described in various tumor entities as potential tumor marker involved in development and progression of cancer. eIF3a is the largest subunit of the eIF3 complex, a key functional entity in 80S establishment and translation initiation. We hypo...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-45636 | biostudies-arrayexpress
UnknownEffect of Gene Silencing of Translation Initiation Factors eIF(iso)4G and eIF(iso)4E on Sour Cherry Rootstock Resistance to Sharka Disease.
Not available
S-EPMC9820581 | biostudies-literature
UnknownC. elegans EIF-3.K promotes programmed cell death through CED-3 caspase.
Not available
S-EPMC3348885 | biostudies-literature
UnknownCalicivirus translation initiation requires an interaction between VPg and eIF 4 E.
Not available
S-EPMC1369186 | biostudies-literature
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