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TranscriptomicsTranscriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression
Within the regulatory framework on the approval of new substances, the assessment of immunotoxic modes of action (MoA) is currently not covered. This is not least due to the lack of standardized methods and reliable validated biomarkers for immunotoxic effects. The experimental set up was designed t...
ORGANISM(S): Danio rerio 
2023-12-01 | E-MTAB-13263 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of zebrafish embryos after 96 h exposure to two subsequent concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12β-trihydroxy-androsta-4,6-diene-3,17-dione (THADD)
The aim of this mRNA expression profiling experiment was to screen for ecotoxicogenomic fingerprints in zebrafish (Danio rerio) embryos as aquatic vertebrate non-target model exposed to sublethal concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12...
ORGANISM(S): Danio rerio 
2021-10-11 | E-MTAB-10922 | biostudies-arrayexpress
TranscriptomicsRNA-seq of zebrafish embryos exposed to different sublethal concentrations of ethinylestradiol for 96 hours against non-treated control groups
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio 
2023-05-10 | E-MTAB-12221 | biostudies-arrayexpress
TranscriptomicsRNA-seq of zebrafish embryos exposed to different sublethal concentrations of flutamide for 96 hours against non-treated control groups
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio 
2023-05-10 | E-MTAB-12235 | biostudies-arrayexpress
TranscriptomicsRNA-seq of zebrafish embryos exposed to different sublethal concentrations of tamoxifen for 96 hours against non-treated control groups
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio 
2023-05-10 | E-MTAB-12227 | biostudies-arrayexpress
TranscriptomicsRNA-seq of zebrafish embryos exposed to different sublethal concentrations of methyltestosterone for 96 hours against non-treated control groups
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio 
2023-05-10 | E-MTAB-12229 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Myriophyllum spicatum exposed to low-effect concentrations of the herbicide bentazone and the pharmaceutical atorvastatin against untreated control groups
Within this study, the non-model organism Myriophyllum spicatum was used to evaluate ecotoxic modes of action at the gene expression level. M. spicatum was exposed to low-effect concentrations of bentazone and atorvastatin in a shortened and modified version of the OECD guideline test No. 239, follo...
ORGANISM(S): Myriophyllum spicatum 
2024-03-20 | E-MTAB-13702 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of zebrafish embryos (96hpf) treated with different concentrations of Triiodothyronine (T3) below acute toxicity levels against untreated control groups
The aim of this sequencing experiment was to screen for ecotoxicogenomic fingerprints for endocrine disrupting chemicals affecting the thyroid system in zebrafish (Danio rerio) embryos as aquatic vertebrate model and alternative to animal testing. Triiodothyronine (T3, CAS: 6893-02-3) was tested as ...
ORGANISM(S): Danio rerio 
2020-09-30 | E-MTAB-9056 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of zebrafish embryos (96hpf) treated with different concentrations of 6-Propyl-2-thiouracil (6-PTU) below acute toxicity levels against untreated control groups
Endocrine disruption can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. Ecotoxicogenomic screening was performed to identify molecular fingerprints for endocrine disrupting chemicals affecting the thyroid system in...
ORGANISM(S): Danio rerio 
2020-09-30 | E-MTAB-9054 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Daphnia magna exposed to abamectin, chlorpyrifos, nicotine, pyriproxyfen and thiacloprid against untreated control groups
The experiment investigates how abamectin, chlorpyrifos, nicotine, pyriproxyfen and thiacloprid affect the gene expression in the freshwater invertebrate Daphnia magna. The experiment aimed to distinguish neurotoxic mechanisms and derive mechanistic information relevant for environmental risk assess...
ORGANISM(S): Daphnia magna 
2026-09-30 | E-MTAB-17707 | biostudies-arrayexpress
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