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TranscriptomicsComparative transcription profiling upon FBLN5 overexpression in transformed COS-7 and normal CV-1 cells
A novel class of genes has recently been identified as anticancer genes, which upon ectopic overexpression selectively destroy the transformed tumour cells, while leaving the untransformed normal cells unharmed. Examples include TRAIL, PAR4 and Orctl3. We have isolated 16 novel anticancer genes of h...
ORGANISM(S): Chlorocebus aethiops 
2023-10-23 | E-MTAB-11449 | biostudies-arrayexpress
TranscriptomicsThe role of HIF in FH-associated renal neoplasia
Fumarate hydratase (FH) mutations predispose to renal cysts cancer. These cancers overexpress hypoxia-inducible factor-alpha (Hif-1a). We have generated a conditional Fh1 (mouse FH) knockout mice that develop renal cysts and overexpress Hif-1a. In order to identify the contribution of Hif-1a to cyst...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-29988 | biostudies-arrayexpress
TranscriptomicsThe DNA methylomes of serous borderline tumours reveal subgroups with malignant-like or benign-like profiles
Serous borderline tumours (SBOT) are a challenging group of ovarian tumours positioned between benign and malignant disease. We have profiled the DNA methylomes of 12 low grade serous carcinoma (LGSC), 19 SBOT and 16 benign serous tumours (BST) across 27,578 CpG sites to further characterise the epi...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-40105 | biostudies-arrayexpress
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