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UnknownPredicting MHC-II binding affinity using multiple instance regression.
Reliably predicting the ability of antigen peptides to bind to major histocompatibility complex class II (MHC-II) molecules is an essential step in developing new vaccines. Uncovering the amino acid sequence correlates of the binding affinity of MHC-II binding peptides is important for understanding...
S-EPMC3400677 | biostudies-literature
UnknownOn evaluating MHC-II binding peptide prediction methods.
Choice of one method over another for MHC-II binding peptide prediction is typically based on published reports of their estimated performance on standard benchmark datasets. We show that several standard benchmark datasets of unique peptides used in such studies contain a substantial number of pept...
S-EPMC2533399 | biostudies-literature
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