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TranscriptomicsELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages
Post-transcriptional gene regulation by miRNAs and RNA binding proteins (RBP) is important in development, physiology and disease. To examine the interplay between miRNAs and the RBP ELAVL1 (a.k.a. HuR), we mapped miRNA binding sites on a transcriptome-wide scale in WT and Elavl1 knockout murine bon...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-63199 | biostudies-arrayexpress
TranscriptomicsELAVL1 iCLIP in HEK293 cells
This experiment aims to map the HuR (ELAVL1) binding to the global transcriptome in HEK293 cells.
ORGANISM(S): Homo sapiens 
2023-04-30 | E-MTAB-11854 | biostudies-arrayexpress
TranscriptomicsUnstressed HeLa cells and ELAVL1/HuR knock down conditions: polyA RNA-Seq, small RNA-Seq, and PAR-CLIP
Post-transcriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA stability regulator. We used PAR-CLIP, a method based on RNA-protein crosslinking, to identify transcriptome wide ~26,000 HuR ...
ORGANISM(S): Homo sapiens 
2011-06-29 | E-GEOD-29943 | biostudies-arrayexpress
GenomicsELAVL1 iCLIP in HEK293 cells
ELAVL1 iCLIP in HEK293 cells
PRJEB53738 | ENA
TranscriptomicsIntegrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability [sequence data]
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-...
ORGANISM(S): Homo sapiens 
2011-08-19 | E-GEOD-29779 | biostudies-arrayexpress
TranscriptomicsHuR (ELAVL1) RIP-chip and knockdown exon array
Integrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability In this dataset, we employed two distinct experiments. 1) HuR RIP-chip to identify mRNA targets of HuR. 2) HuR knockdown to identify mRNAs whose expression are dependent ...
ORGANISM(S): Homo sapiens 
2011-08-18 | E-GEOD-29778 | biostudies-arrayexpress
TranscriptomicsIntestinal epithelial HuR balances counteracting RNA networks to protect against intestinal inflammation and cancer. PART 2 Differentiality in mRNA expression between Control mice and mice overexpressing Elavl1.
Elavl1/HuR is a ubiquitous and conserved RNA-binding protein that binds to a U-rich RNA motif that shuttles between nucleus and cytoplasm. In epithelia, the elevated expression of HuR assumingly promotes degeneration and cancer suggesting that its generic suppression may provide clinical benefits. I...
ORGANISM(S): Mus musculus 
2020-07-01 | E-MTAB-4017 | biostudies-arrayexpress
TranscriptomicsGlobal Target mRNA Specification and Regulation by RNA-Binding Protein ZFP36/Tristetraprolin/TTP [PAR-CLIP]
Tristetraprolin/ZFP36/TTP and ELAVL1/HuR are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich sequences but have antagonistic roles. While ELAVL1 binding has been profiled in several studies, the precise in vivo binding specificity of ZFP36 has not been investigated o...
ORGANISM(S): Homo sapiens 
2013-12-24 | E-GEOD-53184 | biostudies-arrayexpress
ProteomicsRNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I
RIG-I like helicases (RLHs) and cGAS are crucial cytosolic sensors of viral RNA and DNA, respectively, and induce type I IFNs via TBK1/IKKε. hnRNPM was described to possess antimicrobial activities. Here, we show that hnRNPM promotes IRF3 phosphorylation and type I IFN induction downstream of cGAS a...
ORGANISM(S): Homo sapiens (Human) 
2024-11-11 | PXD028160 | Pride
Ap-ms Lc-ms/ms 
GenomicsRIPChip ELAVL1 binding mRNA levels change by GnRH in LbetaT2 cells
RIPChip ELAVL1 binding mRNA levels change by GnRH in LbetaT2 cells
PRJNA526493 | ENA
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