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TranscriptomicsTranscriptional effect of DLX3 transcription factor inhibition by shRNA in ETO2-GLIS2 cell lines
Cells lines expressing the ETO2-GLIS2 oncogene (M07e and WSU-AML) were transduced with an shRNA against Renilla or DLX3 and a GFP reporter. After 48H, cells were sorted on GFP and RNA was extracted. Then library were prepared follow by sequencing.
ORGANISM(S): Homo sapiens 
2025-07-09 | E-MTAB-14189 | biostudies-arrayexpress
TranscriptomicsTranscriptional effect of CBFA2T3::GLIS2 oncogenic fusion engineering by CRISPR-Cas9 in iPSC-derived hematopoietic cells
inv(16)(p13.3;q24.2) leading to the ETO2-GLIS2 fusion was engineered in iPSC cells. iPSC were then differentiated toward hematopoietic lineage and engrafted in immunodeficient recipient mice. Cells are from CTRL and ETO2-GLIS2 cells at day 13 of in vitro differentiation as well as from engrafted imm...
ORGANISM(S): Homo sapiens 
2025-07-09 | E-MTAB-14188 | biostudies-arrayexpress
TranscriptomicsPrimary human CD34+ cells for modeling ETO2-GLIS2 leukemogenesis - Bulk RNAseq
Several fusion oncogenes showing a higher incidence in pediatric acute myeloid leukemia are associated with heterogeneous megakaryoblastic and other myeloid features. Here we addressed how developmental mechanisms influence human leukemogenesis by ETO2::GLIS2, a hallmark of dismal prognosis. We ind...
ORGANISM(S): Homo sapiens 
2024-10-08 | E-MTAB-14131 | biostudies-arrayexpress
TranscriptomicsPrimary human CD34+ cells for modeling ETO2-GLIS2 leukemogenesis - ATACseq
To understand the early consequences of cytokine stimulation, we performed chromatin accessibility assay (ATAC-seq) on primary human CD34+ fetal and cord blood cells exposed or not to IL3 and SCF for 5 days in vitro.
ORGANISM(S): Homo sapiens 
2024-10-08 | E-MTAB-14124 | biostudies-arrayexpress
TranscriptomicsPrimary human CD34+ cells for modeling ETO2-GLIS2 leukemogenesis - Single cell RNAseq
To characterize the consequences of cytokine stimulation, we compared ET02-GLIS2 expressing cells from different origins by single cell transcriptomes (scRNAseq). We analysed FL and CB ET02-GLIS2-expressing CD34+ progeny after 7 days in vitro, human cells from diseased NSG (FL- and FBM-derived) and ...
ORGANISM(S): Homo sapiens 
2024-10-08 | E-MTAB-14140 | biostudies-arrayexpress
no omics definedTranscriptome of HEL cells with inducible expression of ETO2-GLIS2
These data were generated to investigate the impact on the gene expression of the chimeric transcription factor CBFA2T3-GLIS2 (a.k.a ETO2-GLIS2 and abbreviated here as EG) which is associated with pediatric leukemia (LAM7), to assess the functional roles of several domains of this protein (the ETO2 ...
ORGANISM(S): Homo sapiens 
2022-12-31 | E-MTAB-12255 | biostudies-arrayexpress
ProteomicsAnalysis of the MAGED2 interactome
The MAGED2 interactome was analyzed in HEK293T cells using three different strategies.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080703 | MassIVE
UnknownEmergency Departments Leading the Transformation of Alzheimer's and Dementia Care: Emergency Care Redesign.
Not available
S-EPMC13314118 | biostudies-literature
UnknownInsulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.
Not available
S-EPMC11068109 | biostudies-literature
UnknownLack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
Not available
S-EPMC11215417 | biostudies-literature
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