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UnknownThe Staphylococcus aureus IsdH Receptor Forms a Dynamic Complex with Human Hemoglobin that Triggers Heme Release via Two Distinct Hot Spots.
Not available
S-EPMC7309296 | biostudies-literature
UnknownDirected Inter-domain Motions Enable the IsdH Staphylococcus aureus Receptor to Rapidly Extract Heme from Human Hemoglobin.
Not available
S-EPMC9326902 | biostudies-literature
UnknownNegotiation of territorial boundaries in a songbird.
Not available
S-EPMC4235583 | biostudies-literature
TranscriptomicsXenografting of advanced stage breast cancer preserves the genomic and clonal architecture and captures luminal tumors harboring mutations and gene rearrangements in ESR1
End-stage breast cancers are clonally heterogeneous and harbor many poorly-understood treatment resistance mechanisms. We therefore established multiple Patient-Derived-Xenograft (PDX) models to study genomic events driving advanced disease. Comparative whole-genome sequencing of paired primary tu...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-46604 | biostudies-arrayexpress
TranscriptomicsPredicting Response and Survival in Chemotherapy-Treated Triple-Negative Breast Cancer
Gene expression data of pre-treatment samples of GEICAM2006-03 TNBC trial Patients were randomized to carboplatin or no carboplatin in the neoadjuvant setting In the study presented here, a well-defined cohort of 69 breast samples were used to acquire expression profiles of a total of 543 unique gen...
ORGANISM(S): Homo sapiens 
2014-08-11 | E-GEOD-58479 | biostudies-arrayexpress
TranscriptomicsMapping genetic modifiers of ARPKD
Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene in both humans and the orthologous PCK rat model. Although ARPKD results solely from PKHD1 mutations, the disease onset and severity are highly variable, indicating that other unknown genetic risk factor(s...
ORGANISM(S): Rattus norvegicus 
2015-06-06 | E-GEOD-58229 | biostudies-arrayexpress
UnknownRapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry.
Not available
S-EPMC7997806 | biostudies-literature
UnknownDe novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus.
Not available
S-EPMC8967098 | biostudies-literature
UnknownZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models.
Not available
S-EPMC5805526 | biostudies-literature
GenomicsEstrogen Receptor Positive Breast Cancer: Aromatase Inhibitor Response Study

Highly variable outcomes are observed in patients with estrogen receptor positive (ER+) breast cancer who undergo preoperative estrogen deprivation therapy with aromatase inhibitors (AI). In this study, 46 tumor and normal genomes and 31 exomes of participants selected from two clinical trials of...

phs000472.v1.p1 | EGA
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