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TranscriptomicsMAZR and mast cells
Mast cells are known to be the key players in type I hypersensitivity reactions in humans and mice. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis. In this study we investigated the role of the transcriptional regulator MAZR in mast cel...
ORGANISM(S): Mus musculus 
2013-10-18 | E-MTAB-1816 | biostudies-arrayexpress
TranscriptomicsHDAC1/2 and CD4+ T cells
Dynamic changes in histone acetylation patterns are mediated by the activity of histone acetyltransfereases (HATs) and histone deacetylases (HDACs) and are key events in the epigenetic regulation of gene expression. The application of HDAC inhibitors revealed a variety of T cell functions controlled...
ORGANISM(S): Mus musculus 
2014-03-30 | E-MTAB-2184 | biostudies-arrayexpress
TranscriptomicsTime-resolved immune dynamics in rheumatoid arthritis under methotrexate therapy
Methotrexate (MTX) serves as the primary treatment for rheumatoid arthritis (RA), though its mechanism of action is not yet fully understood. The goal of this study was to map the cellular and molecular changes triggered by MTX across different points in time. Using a prospective longitudinal design...
ORGANISM(S): Homo sapiens 
2026-07-01 | E-MTAB-17153 | biostudies-arrayexpress
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