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GenomicsELMSAN1 Regulates Differentiation and Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
ELMSAN1 Regulates Differentiation and Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
PRJNA1093459 | ENA
TranscriptomicsELMSAN1 Regulates Differentiation and Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
Background ELMSAN1 is a newly identified scaffolding protein of the mitotic deacetylase complex (MiDAC), playing a pivotal role in early embryonic development. Studies on Elmsan1 knockout mice showed that its absence results in embryo lethality and heart malformation. However, the precise function o...
ORGANISM(S): Homo sapiens 
2024-07-25 | GSE262838 | GEO
GenomicsLoss of Elmsan1 in Cardiomyocytes Leads to Age-Dependent Cardiac Dysfunction and Reduced Lifespan
Loss of Elmsan1 in Cardiomyocytes Leads to Age-Dependent Cardiac Dysfunction and Reduced Lifespan
PRJNA1285178 | ENA
TranscriptomicsLoss of Elmsan1 in Cardiomyocytes Leads to Age-Dependent Cardiac Dysfunction and Reduced Lifespan
Histone deacetylase (HDAC) complexes regulate pathological gene programs during heart disease progression. The recently identified mitotic deacetylase complex (MiDAC), which includes DNTTIP1, ELMSAN1, and HDAC1/2, remains the least characterized among these complexes. ELMSAN1 has been implicated in ...
ORGANISM(S): Mus musculus 
2025-07-30 | GSE301440 | GEO
GenomicsActivation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq2]
Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq2]
PRJNA1010781 | ENA
GenomicsActivation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq]
Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq]
PRJNA1003917 | ENA
GenomicsActivation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [CUT&RUN]
Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [CUT&RUN]
PRJNA1003911 | ENA
TranscriptomicsActivation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq2]
Developing strategies to enhance the response to bromodomain and extraterminal domain (BET) inhibitors and effectively eradicate cancer stem cells would represent a major cancer treatment advance against leukemia. Through a functional CRISPR screen, we identified the aryl hydrocarbon receptor (AHR),...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE241936 | GEO
TranscriptomicsActivation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq]
Developing strategies to enhance the response to bromodomain and extraterminal domain (BET) inhibitors and effectively eradicate cancer stem cells would represent a major cancer treatment advance against leukemia. Through a functional CRISPR screen, we identified the aryl hydrocarbon receptor (AHR),...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE240496 | GEO
OtherActivation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [CUT&RUN]
Developing strategies to enhance the response to bromodomain and extraterminal domain (BET) inhibitors and effectively eradicate cancer stem cells would represent a major cancer treatment advance against leukemia. Through a functional CRISPR screen, we identified the aryl hydrocarbon receptor (AHR),...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE240495 | GEO
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