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TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
TranscriptomicsRNAseq of Salmo salar parrs with CRISPR/Cas9 induced knockout in the elovl2 gene versus wild type
Atlantic salmon can synthesize polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) via activities of very long chain fatty acyl elongases (elovls) and fatty acyl desaturases (fads), albeit to a limited degree. Un...
ORGANISM(S): Salmo salar 
2019-04-30 | E-MTAB-7220 | biostudies-arrayexpress
GenomicsRNA sequencing analysis of A498 renal cancer cells following knockdown of ELOVL2 and ELOVL5
RNA sequencing analysis of A498 renal cancer cells following knockdown of ELOVL2 and ELOVL5
PRJNA1435190 | ENA
TranscriptomicsRNA sequencing analysis of A498 renal cancer cells following knockdown of ELOVL2 and ELOVL5
Long-chain fatty acid elongases ELOVL2 and ELOVL5 are key regulators of polyunsaturated fatty acid metabolism. To investigate transcriptomic changes induced by depletion of these enzymes, RNA sequencing was performed in A498 renal cancer cells following siRNA-mediated knockdown of ELOVL2 and/or ELOV...
ORGANISM(S): Homo sapiens 
2026-03-16 | GSE324459 | GEO
UnknownELOVL2-AS1 inhibits migration of triple negative breast cancer.
Not available
S-EPMC9013481 | biostudies-literature
GenomicsELOVL2 is a novel tumor suppressor attenuating tamoxifen resistance in breast cancer via suppressing the AKT pathway [gene expression]
ELOVL2 is a novel tumor suppressor attenuating tamoxifen resistance in breast cancer via suppressing the AKT pathway [gene expression]
PRJNA548639 | ENA
UnknownElovl2 Is Required for Robust Visual Function in Zebrafish.
Not available
S-EPMC7761535 | biostudies-literature
TranscriptomicsELOVL2 is a novel tumor suppressor attenuating tamoxifen resistance in breast cancer via suppressing the AKT pathway [gene expression]
Analysis of tamoxifen-sensitivity recovery effect by genes which are regulated by ELOVL2(Elongation of very long chain fatty acids protein 2) at gene expression level in breast cancer. This study identifies that ELOVL2 regulates AKT or ER signaling-related genes and ELOVL2 as an essential gene respo...
ORGANISM(S): Homo sapiens 
2020-06-12 | GSE132614 | GEO
Unknownrs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression.
Not available
S-EPMC7033636 | biostudies-literature
UnknownELOVL2 mediated stabilization of AR contributes to enzalutamide resistance in prostate cancer.
Not available
S-EPMC12183063 | biostudies-literature
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