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MetabolomicsJiawei Shoutai Pill Promotes Embryo Implantation via PPAR Signaling and Endometrial Microbiota Remodeling: An Integrative Multi-Omics Study
Background: Recurrent implantation failure (RIF) remains a major barrier to successful assisted reproductive technology, given the lack of effective, mechanism-informed interventions to enhance endometrial receptivity. Jiawei Shoutai Wan (pills) (JWSTW), a modified formulation of the classic Shoutai...
2026-03-31 | MTBLS14199 | MetaboLights
MetabolomicsMetabolic Changes of Maternal Uterine Fluid, Uterus, and Plasma during the Peri-implantation Period of Early Pregnancy in Mice
Embryo implantation is a complex process which involves biochemical and physiological interactions between an implantation-competent blastocyst and a receptive uterus. However, the exact biochemical changes of uterine fluid, uterus, and plasma during peri-implantation remain unclear. This study aims...
2020-05-04 | MTBLS627 | MetaboLights
MetabolomicsUnique metabolic regulation of micromeres contributes to their inductive signaling in the sea urchin embryo

In many multicellular organisms, a group of cells called organizers plays critical roles by sending signals to adjacent cells and controlling patterning events such as embryogenesis and tissue morphogenesis. Recent studies suggest that these organizers or inductive cells facilitate the downstream...

2025-07-07 | MTBLS5017 | MetaboLights
TranscriptomicsGlobal transcriptome analysis of mouse uterus during embryo implantation by SAGE
The aim of this study was to examine differential gene expression profile in mouse uterus on day 5 of pregnancy between implantation sites and inter-implantation sites. There are 104,520 tags sequenced and acquired, 51,306 for non-implantation site, and 53,214 for implantation site. Keywords: Implan...
ORGANISM(S): Mus musculus 
2005-07-13 | E-GEOD-2892 | biostudies-arrayexpress
TranscriptomicsInteractome of Human Embryo Implantation: Identification of Gene Expression Pathways, Regulation, and Integrated Regulatory Networks.
Possible interactions between endometrium and implanting embryo in humans
ORGANISM(S): Homo sapiens 
2011-12-16 | E-MEXP-3111 | biostudies-arrayexpress
ProteomicsProteomic profiles of endometrium during embryo implantation
Endometrial receptivity plays a vital role in the success of embryo implantation. However, the temporal proteomic profile of porcine endometrium during embryo implantation is still unclear. In this study, the expression of proteins in endometrium on days 9, 10, 11, 12, 13, 14, 15 and 18 of pregnancy...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-05-06 | PXD030681 | Pride
Endometrum  implantation  proteomic profiles  rbp4 
ProteomicsProteomics of a microphysiological model of human trophoblast invasion during early embryo implantation
We have designed an implantation-on-a-chip device to model the invasion of specialized fetal extravillous trophoblasts (EVTs) from an implanting embryo into the maternal decidua. We profiled the proteome of the external factors secreted in the model, containing different cell population compositions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-16 | MSV000086888 | MassIVE
Proteomics,Multiomicsembryo_proteome
We collected over 8000 mouse embryos of each developmental stage (zygote, 2-cell, 4-cell, 8-cell, morula, blastocyst) and performed tandem mass tag (TMT)-based quantitative mass spectrometry and identified nearly 5000 proteins for each stage. In-depth analysis indicates that protein expression profi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-12-10 | MSV000079417 | MassIVE
GenomicsEpigenetic regulation and transcriptional repression by Tet1 in the early post-implantation mouse embryo: Methylation data.
The mammalian TET dioxygenases contribute to global waves of DNA demethylation in the zygote and in primordial germ cells, but their involvement during de novo DNA methylation at peri/post-implantation development is unknown. Here, we show novel physiological functions of Tet1 in the pre-primitive s...
ORGANISM(S): Mus musculus 
2017-05-15 | E-MTAB-4581 | biostudies-arrayexpress
TranscriptomicsRNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation
Successful establishment and maintenance of pregnancy can be attained only through optimum conceptus-maternal cross talk. Despite significant progress in our understanding of the temporal changes in the transcriptome of the uterine endometrium, we have only a rudimentary knowledge of the genes and p...
ORGANISM(S): Bos taurus 
2014-04-04 | E-GEOD-56513 | biostudies-arrayexpress
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