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TranscriptomicsAn EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
Regulation of cell-cell junction formation and regulation of cell migration were enriched among EMT (Epithelial-Mesenchymal Transition)-associated alternatively splicing events. Our analysis suggested that most EMT-associated alternative splicing events are regulated by one or more members of the RB...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30290 | biostudies-arrayexpress
TranscriptomicsEpithelial-mesenchymal transition-associated miRNA signature between EMT(+) and EMT(-) samples in clear-cell renal cell carcinoma
By use of large-scale miRNA expression profiling we identified microRNAs with significantly different expressions in epithelial-mesenchymal transition (EMT)-positive tumors and selected microRNAs for training phase of the study to evaluate their diagnostic and prognostic potential. Further, microRNA...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-MTAB-4911 | biostudies-arrayexpress
TranscriptomicsEpithelial-mesenchymal transition-associated mRNA signature between EMT(+) and EMT(-) samples in clear-cell renal cell carcinoma
By use of large-scale mRNA expression profiling we identified mRNAs with significantly different expression in epithelial-mesenchymal transition (EMT)-positive tumors and selected mRNAs for training phase of the study to evaluate their diagnostic and prognostic potential. Further, mRNAs were forward...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-MTAB-4909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse BALB/c strain animals injected with breast cancer 4T1-derived cells to investigate the role of epithelial to mesenchymal transition (EMT) in spontaneous breast cancer metastasis
Epithelial-mesenchymal transition (EMT) has been linked to cancer progression and metastatic propensity. The 4T1 tumor is a clinically relevant model of spontaneous breast cancer metastasis. Here we characterize 4T1-derived cell lines for EMT, in vitro invasiveness and in vivo metastatic ability. Co...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11259 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression in EMT cells induced by overexpression of PDGF-D compared with PC3 control cells
Analysis of EMTrelated gene expression levels. The hypothesis tested in the present study was that expression of mesenchymal markers was increased and expression of epithelial markers was downregulated concomitant with increased expression of stem -like cell markers in EMT cells compared with contro...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22764 | biostudies-arrayexpress
TranscriptomicsCyclin D1, Id1 and EMT in breast cancer
Cyclin D1 is a well characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer cell...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-27260 | biostudies-arrayexpress
TranscriptomicsE-cadherin and EMT regulation by bHLH factors: a new role for the class I gene E2-2 (TCF4) and its comparison with E47.
Loss of expression of the cell-cell adhesion molecule E-cadherin is an essential event for epithelial-mesenchymal transition (EMT), a process that allows cell migration in the developing embryo and during tumour invasion. Transcriptional repression has emerged as the main mechanism responsible for E...
ORGANISM(S): Canis lupus familiaris 
2010-06-24 | E-GEOD-9145 | biostudies-arrayexpress
TranscriptomicsIntegrative Transcriptomic Profiling reveals Hepatic Stem-like Phenotype and Interplay of EMT and miR-200c in Intrahepatic Cholangiocarcinoma
This SuperSeries is composed of the following subset Series: GSE32879: Integrative Transcriptomic Profiling reveals Hepatic Stem-like Phenotype and Interplay of EMT and miR-200c in Intrahepatic Cholangiocarcinoma [mRNA] GSE32957: Integrative Transcriptomic Profiling reveals Hepatic Stem-like Phenoty...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-32958 | biostudies-arrayexpress
ProteomicsCo-expression analysis of label-free proteomics data reveals prognostic biomarkers in pancreatic ductal adenocarcinoma
Despite extensive biological and clinical studies, including comprehensive genomics and transcriptomics analysis, pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease, with poor survival and no effective therapies to date. Correlation networks are emerging as a powerful approach to ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-15 | MSV000096427 | MassIVE
ProteomicsCharacterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
Introduction: Ampullary cancer is a relatively rare entity and usually treated by pancreatoduodenectomy followed by adjuvant therapy. The intestinal subtype is associated with markedly improved prognosis after resection. Only few cell lines are available for in vitro studies of ampullary cancer and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080802 | MassIVE
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