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To elucidate the mechamisms of colonic Treg cell induction by microbial metabolite(s), chroloform-resistant bacteria (CRB)-associated mice was developed and given low-fiber diet (LFD) and high-fiber diet (HFD). The colonic epithelial cells were isolated and gene expression profiles were analyzed by ...
ORGANISM(S): Mus musculus 
genomic DNA is isolated from C57BL/6 mice intestine at 3.1 months old females and 35.2 months old male. We used MCAM to identify genes that have age-related methylation changes. Two-condition experiment, old vs. young mice intestine.
ORGANISM(S): Mus musculus 
Genomic DNA is isolated from bone marrow (MDS patient) and whole blood (normal control). We used MCAM to identify genes that have methylation changes. Two-condition experiment, MDS patient vs. normal control.
ORGANISM(S): Homo sapiens 
Genomic DNA is isolated from spleen (RUNX1 model and normal control) and bone marrow (NHD13 model and normal control). We used MCAM to identify genes that have methylation changes. Two-condition experiment, MDS model mouse vs. normal control.
ORGANISM(S): Mus musculus 
Angiogenic homeostasis is maintained by a balance between vascular endothelial growth factor (VEGF) and Notch signalling in endothelial cells (ECs). We screened for molecules that might mediate the coupling of VEGF signal transduction with down-regulation of Notch signalling, and identified B-cell c...
ORGANISM(S): Homo sapiens 
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