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MetabolomicsEffect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota, but causality remains yet to be established. Here, using unpredictable chronic mild stress (UCMS) as a mouse mod...

2021-01-21 | MTBLS121 | MetaboLights
TranscriptomicsTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
We evaluated cutaneous contact hypersensitivity (CHS) in Cnr1-/-/Cnr2-/- animals using the obligate contact allergen 2,4-dinitrofluorobenzene (DNFB), which generates a specific cutaneous T-cell mediated allergic response upon repeated allergen contact. Allergic contact dermatitis affects about 5% of...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-7694 | biostudies-arrayexpress
MetabolomicsQuantitative profiling of endocannabinoids in lipoproteins by LC–MS/MS
Endocannabinoids belong to a diverse family of endogenous lipid bioregulators acting as physiological ligands of cannabinoid receptor type 1 and cannabinoid receptor type 2 in the central and peripheral nervous system. They are also present in nmol/l concentrations in human blood plasma; however, th...
2015-03-11 | MTBLS163 | MetaboLights
TranscriptomicsSilencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration
Endocannabinoid signaling plays a key role in multiple events in female reproduction. In this investigation, we discovered an interesting phenomenon that mice with either elevated or silenced endocannabinoid signaling show similar defects in multiple pregnancy events, including preimplantation embry...
ORGANISM(S): Mus musculus 
2012-07-25 | E-GEOD-36399 | biostudies-arrayexpress
TranscriptomicsMutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism
PHARC is a neurodegenerative disease comprising early onset cataract and hearing loss, retinitis pigmentosa, and involvement of both the central and peripheral nervous systems; including demyelinating sensorimotor polyneuropathy and cerebellar ataxia. Previously, we mapped this Refsum-like disorder ...
ORGANISM(S): Homo sapiens 
2010-08-26 | E-GEOD-23151 | biostudies-arrayexpress
GenomicsEffect of endocannabinoid AEA on HIV1 TAT activated Normal Human Primary Astrocytes
Effect of endocannabinoid AEA on HIV1 TAT activated Normal Human Primary Astrocytes
PRJNA863645 | ENA
UnknownEndocannabinoid signalling and the deteriorating brain.
Not available
S-EPMC4471876 | biostudies-literature
UnknownDysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin.
Not available
S-EPMC10447569 | biostudies-literature
GenomicsEndocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling
Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling
PRJNA1048496 | ENA
ProteomicsEndocannabinoid biosynthetic enzymes regulate pain response via LKB1–AMPK signaling
Diacylglycerol lipase-beta (DAGLβ) serves as a principal 2-arachidonoylglycerol (2-AG) biosynthetic enzyme regulating endocannabinoid and eicosanoid metabolism in immune cells including macrophages and dendritic cells. Genetic or pharmacological inactivation of DAGLβ ameliorates inflammation and hyp...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-02 | PXD047413 | Pride
Inflammation Ampk Endocannabinoids Diacylglycerol lipase Activity based protein profiling 
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