Sort   by:  
 Page size 
MetabolomicsEffect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota, but causality remains yet to be established. Here, using unpredictable chronic mild stress (UCMS) as a mouse mod...

2021-01-21 | MTBLS121 | MetaboLights
MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
TranscriptomicsSilencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration
Endocannabinoid signaling plays a key role in multiple events in female reproduction. In this investigation, we discovered an interesting phenomenon that mice with either elevated or silenced endocannabinoid signaling show similar defects in multiple pregnancy events, including preimplantation embry...
ORGANISM(S): Mus musculus 
2012-07-25 | E-GEOD-36399 | biostudies-arrayexpress
GenomicsEndocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling
Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling
PRJNA1048496 | ENA
ProteomicsEndocannabinoid biosynthetic enzymes regulate pain response via LKB1–AMPK signaling
Diacylglycerol lipase-beta (DAGLβ) serves as a principal 2-arachidonoylglycerol (2-AG) biosynthetic enzyme regulating endocannabinoid and eicosanoid metabolism in immune cells including macrophages and dendritic cells. Genetic or pharmacological inactivation of DAGLβ ameliorates inflammation and hyp...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-02 | PXD047413 | Pride
Inflammation Ampk Endocannabinoids Diacylglycerol lipase Activity based protein profiling 
UnknownDysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin.
Not available
S-EPMC10447569 | biostudies-literature
TranscriptomicsSilencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration
Endocannabinoid signaling plays a key role in multiple events in female reproduction. In this investigation, we discovered an interesting phenomenon that mice with either elevated or silenced endocannabinoid signaling show similar defects in multiple pregnancy events, including preimplantation embry...
ORGANISM(S): Mus musculus 
2012-07-26 | GSE36399 | GEO
UnknownOrexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency.
Not available
S-EPMC5130126 | biostudies-literature
TranscriptomicsEndocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling
Diacylglycerol lipase-beta (DAGLB) serves as a principal 2-arachidonoylglycerol (2-AG) biosynthetic enzyme regulating endocannabinoid and eicosanoid metabolism in immune cells including macrophages and dendritic cells. Genetic or pharmacological inactivation of DAGLb ameliorates inflammation and hyp...
ORGANISM(S): Mus musculus 
2024-01-02 | GSE249312 | GEO
UnknownPostsynaptic synucleins mediate endocannabinoid signaling.
Not available
S-EPMC10244176 | biostudies-literature
Sort   by:  
 Page size