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MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
ProteomicsProteomic datasets for the identification of endometrial cancer in minimally invasive samples (cervico-vaginal fluid and blood plasma).
The aim of the underlying study was to identify protein signatures for the detection of endometrial cancer in minimally invasive samples such as cervico-vaginal fluid and blood plasma. Plasma and Delphi Screener-collected cervico-vaginal fluid samples were acquired from post-menopausal women who wer...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050276 | Pride
Proteomics Endometrial cancer Swath Plasma Cervico-vaginal fluid 
MetabolomicsMetabolic Changes of Maternal Uterine Fluid, Uterus, and Plasma during the Peri-implantation Period of Early Pregnancy in Mice
Embryo implantation is a complex process which involves biochemical and physiological interactions between an implantation-competent blastocyst and a receptive uterus. However, the exact biochemical changes of uterine fluid, uterus, and plasma during peri-implantation remain unclear. This study aims...
2020-05-04 | MTBLS627 | MetaboLights
ProteomicsComprehensive spectral library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid
This study focuses on the potential of detecting endometrial cancer based on the proteins and peptides expressed in cervico-vaginal fluid.Sequential window acquisition of all theoretical mass spectra (SWATH-MS), an accurate and reproducible platform for analysing biological samples, offers a technol...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025925 | Pride
Endemetrial cancer Proteomics Spectral library Biomarkers Cervico-vaginal fluid 
ProteomicsIn-depth proteomics and natural peptidomics analyses of human endometrial fluid
Endometrial fluid reflects the status of the endometrium, being a good atraumatic source of information on embryo implantation and some pathological conditions. Although some attempts have been made to characterize it, the catalogue of the human endometrial fluid proteins remains incomplete and litt...
ORGANISM(S): Homo sapiens (Human) 
2020-09-29 | PXD016707 | Pride
Natural peptidomics Timstof Endometrial fluid 
TranscriptomicsCOUP-TFII regulates human endometrial stromal genes involved in inflammation
Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown.To interrogate the role of COUP-TFII in human endometrial function, we utilized a siRNA-mediated loss of function approach in primary human endometrial stromal cells...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-47052 | biostudies-arrayexpress
TranscriptomicsChanges in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, Papio anubis
Endometriosis is associated with aberrant gene expression in the eutopic endometrium of women with disease. To determine if the development of endometriotic lesions directly impacts eutopic endometrial gene expression, we sequentially analyzed the eutopic endometrium across the time course of diseas...
ORGANISM(S): Papio anubis 
2015-08-27 | E-GEOD-72428 | biostudies-arrayexpress
TranscriptomicsTLR4 Signaling Is a Major Mediator of the Female Tract Response to Seminal Fluid in Mice
To examine the effect of seminal fluid on the whole genome expression profile of endometrial tissue following mating, RNA was extracted from endometrial tissue collected 8 h after CBAF1 females were mated with intact Balb/c males and compared to RNA from endometrial tissue of females mated with semi...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-70401 | biostudies-arrayexpress
TranscriptomicsReciprocal communication between endometrial stromal cells and macrophages
Endometriosis is an inflammatory disease and bone marrow-derived cells are abundant in endometriotic lesions and in the peritoneal fluid of women with the disease. This study tested the hypothesis that reciprocal communication occurs between macrophages and cultured human endometrial stromal cells ...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-19834 | biostudies-arrayexpress
ProteomicsQuantitative SWATH-Based Proteomic Profiling of Urine for the Identification of Endometrial Cancer Biomarkers in Symptomatic Women
In this study, we carried out quantitative SWATH-MS-based proteomic profiling of urine acquired from a cohort of symptomatic women with and without endometrial cancer.
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038860 | Pride
Urine Swath Endometrial cancer 
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