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TranscriptomicsTranscription profiling of human EBV transformed cell lines established from patients with a novel immunodeficiency syndrome
Lysosome-related organelles have versatile functions including protein and lipid degradation, signal transduction, and protein secretion. The molecular elucidation of rare congenital diseases affecting endosomal/lysosomal biogenesis has given insights into physiological functions of the innate and a...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6322 | biostudies-arrayexpress
MetabolomicsHyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway
When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid, yet the key molecular regulators remain undefined. Here, we reveal that early disseminated OC cells are ingeniously utilize hyaluronic aci...
2026-07-10 | MTBLS15007 | MetaboLights
ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
2024-10-15 | PXD056836 |
TranscriptomicsWnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high content genome-wide RNAi screens that monitored lipid distribution and amounts, we find...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-MTAB-2872 | biostudies-arrayexpress
GenomicsImpaired endosomal recycling of signaling receptors activates an extracellular UPR
Impaired endosomal recycling of signaling receptors activates an extracellular UPR
PRJNA1475055 | ENA
GenomicsApolipoprotein E2 protects against aging-induced neuronal endosomal dysfunction through enhanced exosome secretion
Apolipoprotein E2 protects against aging-induced neuronal endosomal dysfunction through enhanced exosome secretion
PRJNA778111 | ENA
UnknownA Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.
Not available
S-EPMC5290275 | biostudies-literature
ProteomicsTau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic
Comparison of proteins from pooled CSF from 4 control mice and 5 VPS35 Camk2a KO mice
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-10 | MSV000085709 | MassIVE
UnknownThe Endosomal Recycling Pathway-At the Crossroads of the Cell.
Not available
S-EPMC7503921 | biostudies-literature
UnknownCaveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation
Not available
S-JCBD-201003086 | bioimages
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