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ProteomicsEndocytic Turnover of Endothelial Cell-Membrane Proteins as a Driver of Blood Brain Barrier Specialization and Dysfunction
The blood-brain barrier (BBB), formed primarily by specialized brain endothelial cells (BEC), exerts essential functions for proper brain activity, including nutrient transport, signal transduction, immune cell transmigration and pathogen restriction. While these functions are known to be regulated ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-15 | PXD067112 | Pride
Blood-brain barrier Brain endothelial cells Endocytic turnover rate 
TranscriptomicsBBBomics - Human Blood Brain Barrier Transcriptomics Hub [RNA-seq]
Functional and structural dysfunction of the blood brain barrier (BBB) leads to severe alterations in brain physiology and is believed to trigger neurodegeneration. To investigate the molecular mechanisms driving the BBB dysfunction, very few human BBB cell culture models are available; of which, th...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-76528 | biostudies-arrayexpress
TranscriptomicsBBBomics - Human Blood Brain Barrier Transcriptomics Hub [miRNA-seq]
Functional and structural dysfunction of the blood brain barrier (BBB) leads to severe alterations in brain physiology and is believed to trigger neurodegeneration. To investigate the molecular mechanisms driving the BBB dysfunction, very few human BBB cell culture models are available;of which, the...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-76530 | biostudies-arrayexpress
TranscriptomicsInterferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier
Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress
ProteomicsMultiomics Profiling of Extracellular Vesicles Supports Their Involvement in Endothelial Senescence-Associated Vascular Dysfunction
Dysfunction of vascular endothelium is characteristic of many aging-related diseases, including Alzheimers disease (AD) and AD-related dementias (ADRD). While it is widely posited that endothelial cell dysfunction contributes to the pathogenesis and/or progression of AD/ADRD, it is not clear how. A ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-23 | MSV000095687 | MassIVE
GenomicsIncreased Type I Interferon Signaling and Brain Endothelial Barrier Dysfunction in an Experimental Model of Alzheimer’s Disease
Increased Type I Interferon Signaling and Brain Endothelial Barrier Dysfunction in an Experimental Model of Alzheimer’s Disease
PRJNA851593 | ENA
TranscriptomicsRNA-seq of human brain endothelial cells treated with Nrf2 activator RTA-404
Systemic inflammation can lead to a compromised blood-brain barrier (BBB) and neuro-inflammation, with acute consequences such as delirium, and long-lasting deleterious effects including cognitive decline and the exacerbation of neurodegenerative disease progression. Previous studies have shown bene...
ORGANISM(S): Homo sapiens 
2025-03-27 | E-MTAB-14978 | biostudies-arrayexpress
UnknownCitrullinated histone 3 causes endothelial barrier dysfunction.
Not available
S-EPMC6119499 | biostudies-literature
TranscriptomicsQuiescent endothelial cells upregulate fatty acid β-oxidation for vasculoprotection via redox homeostasis
Little is known about metabolic changes accompanying endothelial cell (EC) quiescence. Nonetheless, when dysfunctional, quiescent ECs (QECs) contribute to multiple cardiovascular diseases. ECs need fatty acid β-oxidation (FAO) for proliferation. Surprisingly, we now report that QECs are not hypo-met...
ORGANISM(S): Mus musculus 
2018-09-12 | E-MTAB-6595 | biostudies-arrayexpress
ProteomicsThe role of aging on endothelial cell-cell junctions and pulmonary microvascular permeability
Acute respiratory distress syndrome (ARDS) is a leading cause of intensive care unit (ICU) admissions and is associated with high short- and long-term mortality, particularly among elderly patients. Aging is a major risk factor for ARDS development and worsened outcomes, yet the mechanisms underlyin...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD065409 | Pride
Acute respiratory distress syndrome (ards) Endothelial barrier dysfunction Proteomics Inflammation Cytoskeleton Aging 
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