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MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
TranscriptomicsIntrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model
Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in th...
ORGANISM(S): Oryctolagus cuniculus 
2013-10-30 | E-GEOD-37860 | biostudies-arrayexpress
MetabolomicsLimited survival and impaired hepatic fasting metabolism of glucose, amino acids and lipids in mice with constitutive Rag GTPase signaling
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (RagAGTP) in mice resulted in a fatal energetic crisis...
2021-05-11 | MTBLS2397 | MetaboLights
TranscriptomicsEnergy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough
This SuperSeries is composed of the following subset Series: GSE8015: Pyruvate fermentation vs Lactate-Sulfate GSE8037: Hydrogen vs Lactate as electron donor in Sulfate reduction GSE8071: Pyruvate vs Lactate as electron donor in Sulfate reduction GSE8072: Thiosulfate vs Sulfate as electron acceptor ...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-04-05 | E-GEOD-8069 | biostudies-arrayexpress
MetabolomicsDeletion of Gja1 in myocardium emerges ventricular arrhythmia and tachycardia by reprogramming proline metabolism
Connexin43 (Cx43) is the predominant connexin in working myocardium. Its expression decreases in various cardiovascular diseases, and accompanied by ventricular arrhythmias (VAs). However, molecular mechanisms underlying increased arrhythmogenesis remained unclear. Here we established iPSC-derived c...
2025-11-11 | MTBLS13302 | MetaboLights
TranscriptomicsPyruvate fermentation vs Lactate-Sulfate
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8015 | biostudies-arrayexpress
Transcriptomicsabi4-Energetic Homeostasis and Sugar Signaling
bra-inra09-01_bioen - abi4 - Diversification of the Molecular Mechanisms Involved in the Control of the Energetic Balance in Angiosperms - Abi4 is regulator pleotropic that interview in the metabolism glucose 12 dye-swap - wt vs mutant comparison
ORGANISM(S): Arabidopsis thaliana 
2012-01-01 | E-GEOD-26044 | biostudies-arrayexpress
TranscriptomicsPyruvate vs Lactate as electron donor in Sulfate reduction
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8071 | biostudies-arrayexpress
TranscriptomicsThiosulfate vs Sulfate as electron acceptor in Sulfate reduction
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8072 | biostudies-arrayexpress
TranscriptomicsHydrogen vs Lactate as electron donor in Sulfate reduction
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8037 | biostudies-arrayexpress
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