Engineered heart tissue

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Organisms

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Tissue

Heart (16)
Cardiac muscle tissue of ventricle (2)
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Cell culture (2)
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Cardiovascular system disease (6)
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Mass Spectrometry (27)
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2014 (4)
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CHEBI ID

CHEBI:57608 (1)
CHEBI:48042 (1)
CHEBI:132941 (1)
CHEBI:55404 (1)
CHEBI:18105 (1)
CHEBI:57737 (1)
CHEBI:21519 (1)
CHEBI:35425 (1)
CHEBI:62168 (1)
CHEBI:17973 (1)
CHEBI:17797 (1)
CHEBI:15954 (1)
CHEBI:17983 (1)
CHEBI:15820 (1)
CHEBI:35374 (1)
CHEBI:16082 (1)
CHEBI:29042 (1)
CHEBI:84838 (1)
CHEBI:16556 (1)
CHEBI:18307 (1)
CHEBI:17009 (1)
CHEBI:88003 (1)
CHEBI:18066 (1)
CHEBI:17200 (1)
CHEBI:15784 (1)
CHEBI:17363 (1)
CHEBI:22660 (1)
CHEBI:16960 (1)
CHEBI:16695 (1)
CHEBI:7676 (1)

Metabolite Name

C00049 (1)
1,4-Dihydronicotinamide adenine dinucleotide (NADH) (1)
HMDB0000511 (1)
Cis-aconitic acid (1)
O-butanoyl-L-carnitine (1)
O-isobutyryl-L-carnitine (1)
Pyruvic acid (1)
Nicotinamide adenine dinucleotide (NAD) (1)
2-Hydroxyglutaric acid (1)
Alpha-ketoglutaric acid (1)
Succinic acid (1)
Fumaric acid (1)
Citric acid (1)
Isocitric acid (1)
Malic acid (1)
Adenosine (1)
Glutamic acid (1)
Aspartic acid (1)
Guanosine (1)

First Public Date

2026 (14)
2025 (11)
2024 (11)
2023 (7)
2022 (6)
2020 (5)
2021 (2)
2014 (2)
2017 (1)
2016 (1)
2015 (1)

Study type

Transcription profiling by array (26)
Unknown experiment type (5)
RNA-seq of coding RNA (4)
RNAi profiling by array (1)
Other (1)

Release Date

2023 (66)
2020 (65)
2021 (61)
2022 (56)
2024 (53)
2019 (52)
2018 (50)
2025 (44)
2017 (38)
2016 (33)
2014 (26)
2015 (23)
2026 (15)
2011 (13)
2012 (12)
2010 (12)
2013 (10)
2009 (5)
2008 (3)
2007 (1)
2006 (1)
2004 (1)
2001 (1)

Lab affiliation

Executive Science Officer, BioFrontiers InstituteDistinguished ProfessorProfessor, Howard Hughes Medical Institute MOLECULAR CELLULAR AND DEVELOPMENTAL BIOLOGY CU DENVER SCHOOL OF MEDICINE (2)
King’s British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (2)
Assistant Professor, Biochemistry Boston University School of Medicine Investigator, National Emerging Infectious Diseases Laboratories (NEIDL), USA (1)
Department of Biotechnology, Yonsei University, Republic of Korea (1)
Department of Experimental Pharmacology and 35 Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 36 Martinistrasse 52, 20246 Hamburg, Germany (1)
Assistant Professor Department of Medicine | Cardiology | Cardiometabolic Precision Medicine Program Department of Systems Biology Herbert Irving Comprehensive Cancer Center | Precision Oncology and Systems Biology Program Data Science Institute | Health Analytics Center Columbia Stem Cell Initiative Columbia University Irving Medical Center 630 West 168th Street, P&S 10-401, New York, NY 10032 (1)
Department of Chemistry, Southern University of Science and Technology (1)
School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia. (1)
NIH/NIDCR (1)
Head of the Laboratory for Vascular Biology, Department of Experimental Medicine,Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation (1)
Chief Scientific Officer, BioFrontiers Institute Distinguished Professor, Department of Molecular, Cellular, and Developmental Biology Professor, Howard Hughes Medical Institute (1)
Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ 85004, USA (1)
Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)
Pohang University of Science and Technology (1)
Department of Immunology, University of Toronto, Canada Toronto General Hosptial Research Institute, University Health Network, Canada (1)
Department of Immunology, University of Toronto, Canada Toronto General Hospital Research Institute, University Health Network, Canada (1)
Institute of Pharmacology & Toxicology, University Medical Center Göttingen, Germany. Medical Clinic I, Department of Cardiology and Angiology, Justus Liebig University, Giessen, Germany. German Centre for Cardiovascular Research (DZHK e.V.), partner sites Lower Saxony, Heidelberg/Mannheim, Munich, Hamburg/Kiel/Lübeck, RhineMain, Germany. Cardio-Pulmonary Institute (CPI), Giessen, Germany. (1)
Lab for Retinal Cell Biology Dept. Ophthalmology USZ / UZH University of Zurich (1)
National Heart and Lung Institute, Imperial College London, London, UK (1)
Baker Heart & Diabetes Inst. (1)
Department of Molecular Mechanisms of Disease, University of Zurich, Switzerland (1)
CNIC (1)
Dr. Elke Hammer Universitätsmedizin Greifswald Interfakultäres Institut für Genetik und Funktionelle Genomforschung Abteilung für Funktionelle Genomforschung Felix-Hausdorff-Straße 8 17487 Greifswald (1)
University of Wisconsin-Madison (1)
Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München (1)

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Cross-modal Integration of Metabolomics and Cardiac Functionality Captures Dynamic Metabotoxic Effects of Doxorubicin in Engineered Heart Tissues

Functional stem cell-derived heart models offer new avenues for preclinical, animal-free physiological assessment of drug cardiotoxicity. Yet, comprehensive molecular profiling in these models remains limited, leaving key metabolic drivers of cardiotoxicity unexplored.

Here, we leveraged an...

2025-12-07 | MTBLS13225 | MetaboLights

Lactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs

top down and bottom up proteomics files for Lactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-05-05 | MSV000091869 | MassIVE

Immunobiology of fibrin-based engineered heart tissue.

Not available

S-EPMC4449088 | biostudies-literature

Digital Light Processing 3D Printing Enables Versatile Fabrication of Human Engineered Heart Tissues

While cell models are routinely used to study cardiac molecular biology, in vitro systems fall far short of mimicking the metabolic and sarcomere structural maturity of intact cardiac tissue. Achieving a mature cardiomyocyte (CM) phenotype is essential for creating a physiologically relevant environ...

ORGANISM(S): Homo sapiens (Human)

2026-09-21 | PXD074288 | Pride

Human engineered heart tissues Digital light processing

Expression data from cyclically stretched engineered neonatal rat ventricuar myocyte (NRVM) tissues

Mechanical overload in the heart induces pathological remodeling that typcially leads to heart failure. We sought to build an in vitro model of heart failure by applying cyclic stretch to engineered isotropic (iso) and anisotropic (aniso) NRVM tissues. We used micoarrays to determine the effects of ...

ORGANISM(S): Rattus norvegicus

2013-01-30 | E-GEOD-43846 | biostudies-arrayexpress

Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications

Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of f...

ORGANISM(S): Sus scrofa domesticus (domestic pig)

2024-02-03 | PXD042077 | Pride

Decellularization

Parthenogenetic stem cells for tissue-engineered heart repair

Uniparental parthenotes are considered an unwanted byproduct of in vitro fertilization. In utero parthenote development is severely compromised by defective organogenesis and in particular by defective cardiogenesis. Although developmentally compromised, apparently pluripotent stem cells can be deri...

ORGANISM(S): Mus musculus

2013-02-23 | E-GEOD-30868 | biostudies-arrayexpress

Bulk RNA-seq of human engineered heart tissue for analyzing human myocardial fibrosis

PRJNA982808 | ENA

Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves.

Not available

S-EPMC6104173 | biostudies-literature

In vivo grafting of large engineered heart tissue patches for cardiac repair.

Not available

S-EPMC8410032 | biostudies-literature