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MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
TranscriptomicsDevelopment of gene expression signatures for subconfluent and overconfluent HT-1080 fibrosarcoma cell line
We investigated the changes in gene expression profile between subconfluent (80%) and overconfluent HT-1080 fibrosarcoma cell line. We have employed whole genome microarray expression profiling as a discovery platform to identify genes expression profiles in HT-1080 cells. Total RNAs from subconflue...
ORGANISM(S): Homo sapiens 
2015-06-04 | E-GEOD-69534 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for contact-inhibited and adipogenic-differentiated 3T3-L1 and NIH3T3 fibroblasts
Given previous works showing that, in the process of adipogenic differentiation of 3T3-L1 fibroblasts, the cells need to be cultured to confluency followed by additional incubation before initiating differentiation, we hypothesized that contact inhibition of proliferation (CIP) is requisite for maki...
ORGANISM(S): Mus musculus 
2015-05-28 | E-GEOD-69320 | biostudies-arrayexpress
MetabolomicsFruit setting rewires central metabolism via gibberellin cascades
Fruit set is the process whereby ovaries develop into fruits after pollination and fertilization. The process is induced by the phytohormone gibberellin (GA) in tomatoes, as determined by the constitutive GA response mutant procera However, the role of GA on the metabolic behavior in fruit-setting o...
2020-09-11 | MTBLS1892 | MetaboLights
ProteomicsProteomic analysis of desmoid tumors in a novel mouse model.
Proteomic analysis was performed on desmoid tumors developed in Ctnnb1 or Ctnnb1/Smad4 compound mutant mice.
ORGANISM(S): Mus Musculus (mouse) 
2024-07-07 | PXD043079 | JPOST Repository
ProteomicsSerum proteome profiling of patients with non-small cell lung cancer treated with immune checkpoint blockade monotherapy
Shotgun proteomic profiling of serum from patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint blockade (ICB) monotherapy. Top-14 abundant proteins were depleted (Pierce High-Select, Thermo Fisher Scientific), and tryptic digests were spiked with the Pierce Peptide Retenti...
ORGANISM(S): Homo Sapiens (human) 
2026-06-10 | PXD078247 | JPOST Repository
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